T
Tomas Simonsson
Researcher at University of Gothenburg
Publications - 23
Citations - 2814
Tomas Simonsson is an academic researcher from University of Gothenburg. The author has contributed to research in topics: DNA & Telomere. The author has an hindex of 18, co-authored 23 publications receiving 2670 citations. Previous affiliations of Tomas Simonsson include Laboratory of Molecular Biology & Chalmers University of Technology.
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G-quadruplex DNA structures--variations on a theme.
TL;DR: The plethora of Gquadruplex DNA structures is explored, and their possible biological functions as well as the proteins that interact with them are discussed.
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DNA tetraplex formation in the control region of c-myc.
TL;DR: It is shown that the targeted control element adopts an intrastrand fold-back DNA tetraplex, which requires potassium ions for stability in vitro, and proposed a transcription initiation mechanism that explains how anti-gene therapy silence c-myc at the molecular level.
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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
TL;DR: RNA interference is used to explore in vivo functions of two ciliate TEBPs, TEBPα and TEBPβ, and shows that they cooperate to control the formation of an antiparallel guanine quadruplex DNA structure at telomeres in vivo.
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Identification and Characterization of Genomic Nucleosome-positioning Sequences
Hans R. Widlund,Hui Cao,Stina Simonsson,Elisabet Sager Magnusson,Tomas Simonsson,Peter E. Nielsen,Jason D. Kahn,Donald M. Crothers,Mikael Kubista +8 more
TL;DR: This work isolated the DNA segments in the mouse genome that form the most stable nucleosomes yet characterized and selected sequences are shown to be localized at the centromeric regions of mouse metaphase chromosomes.
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G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation
TL;DR: It is demonstrated that a G-quadruplex structure formed in nascent RNA upon transcription of CSB II causes transcription termination at conserved sequence block II in the mitochondrial DNA control region, reminiscent of Rho-independent transcription termination in prokaryotes.