T
Tomoko Ichisaka
Researcher at Kyoto University
Publications - 30
Citations - 38586
Tomoko Ichisaka is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 23, co-authored 29 publications receiving 35135 citations.
Papers
More filters
Journal ArticleDOI
Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
Hisayuki Amano,Hisayuki Amano,Ken Itakura,Masayoshi Maruyama,Tomoko Ichisaka,Masato Nakagawa,Shinya Yamanaka +6 more
TL;DR: The mouse ESG1 gene, together with a duplicated pseudogene, is located on chromosome 9 and is dispensable for self-renewal of ES cells and establishment of germcells, despite specific expression in pluripotent cells and germ cells.
Journal ArticleDOI
Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.
TL;DR: It is demonstrated that Nanog plays a key role in stabilizing Epiblast pluripotency mediated by Nodal/Smad2 signaling, which is involved in Nanog promoter switching in early developing embryos.
Journal ArticleDOI
Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models
Tomonaga Ameku,Daisuke Taura,Masakatsu Sone,Tomohiro Numata,Masahiro Nakamura,Fumihiko Shiota,Taro Toyoda,Satoshi Matsui,Toshikazu Araoka,Tetsuhiko Yasuno,Shin Ichi Mae,Hatasu Kobayashi,Naoya Kondo,Fumiyo Kitaoka,Naoki Amano,Sayaka Arai,Tomoko Ichisaka,Norio Matsuura,Sumiko Inoue,Takuya Yamamoto,Kazutoshi Takahashi,Isao Asaka,Yasuhiro Yamada,Yoshifumi Ubara,Eri Muso,Atsushi Fukatsu,Akira Watanabe,Yasunori Sato,Tatsutoshi Nakahata,Yasuo Mori,Akio Koizumi,Kazuwa Nakao,Shinya Yamanaka,Kenji Osafune +33 more
TL;DR: It is found that the expression level of a metalloenzyme gene, matrix metalloproteinase (MMP) 1, was specifically elevated in iPSC-derived endothelia from ADPKD patients with ICAs, indicating that high serum MMP1 levels may be a novel risk factor.
Journal ArticleDOI
Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor
Kimitoshi Denda,Kanako Nakao-Wakabayashi,Naoki Okamoto,Naomi Kitamura,Je-Young Ryu,Yoh-ichi Tagawa,Tomoko Ichisaka,Shinya Yamanaka,Masayuki Komada +8 more
TL;DR: Evidence is provided for a novel labor-inducing fetoplacental signal that depends on the X chromosome and possibly arises from the placenta, which is essential in the fetus/placenta for labor in mice.
Journal ArticleDOI
ECAT11/L1td1 Is Enriched in ESCs and Rapidly Activated During iPSCGeneration, but It Is Dispensable for the Maintenance and Induction of Pluripotency
Kumiko Iwabuchi,Tatsuya Yamakawa,Yoshiko Sato,Tomoko Ichisaka,Kazutoshi Takahashi,Keisuke Okita,Shinya Yamanaka +6 more
TL;DR: It is found that ECAT11 (L1td1) is one of the ESC-associated transcripts harboring a truncated fragment of ORF-1, a component of theL1 retrotransposable element that is dispensable for both the proliferation and pluripotency of ESCs.