T
Toshikazu Araoka
Researcher at Kyoto University
Publications - 20
Citations - 2438
Toshikazu Araoka is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Progenitor cell. The author has an hindex of 12, co-authored 17 publications receiving 1780 citations. Previous affiliations of Toshikazu Araoka include Universidad Católica San Antonio de Murcia & Salk Institute for Biological Studies.
Papers
More filters
Journal ArticleDOI
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Keiichiro Suzuki,Yuji Tsunekawa,Reyna Hernández-Benítez,Reyna Hernández-Benítez,Jun Wu,Jun Wu,Jie Zhu,Jie Zhu,Euiseok J. Kim,Fumiyuki Hatanaka,Mako Yamamoto,Toshikazu Araoka,Toshikazu Araoka,Zhe Li,Masakazu Kurita,Tomoaki Hishida,Mo Li,Emi Aizawa,Shicheng Guo,Song Chen,April Goebl,Rupa Devi Soligalla,Jing Qu,Tingshuai Jiang,Xin Fu,Xin Fu,Maryam Jafari,Concepcion Rodriguez Esteban,W. Travis Berggren,Jeronimo Lajara,Estrella Núñez-Delicado,Pedro Guillen,Josep M. Campistol,Fumio Matsuzaki,Guang-Hui Liu,Pierre J. Magistretti,Kun Zhang,Edward M. Callaway,Kang Zhang,Juan Carlos Izpisua Belmonte +39 more
TL;DR: The HITI method presented here establishes new avenues for basic research and targeted gene therapies and demonstrates the efficacy of HITI in improving visual function using a rat model of the retinal degeneration condition retinitis pigmentosa.
Journal ArticleDOI
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Alejandro Ocampo,Pradeep Reddy,Paloma Martinez-Redondo,Aida Platero-Luengo,Fumiyuki Hatanaka,Tomoaki Hishida,Mo Li,David Lam,Masakazu Kurita,Masakazu Kurita,Ergin Beyret,Toshikazu Araoka,Toshikazu Araoka,Eric Vazquez-Ferrer,David Donoso,Jose Luis Roman,Jinna Xu,Concepcion Rodriguez Esteban,Gabriel Núñez,Estrella Nuñez Delicado,Josep M. Campistol,Isabel Guillen,Pedro Guillen,Juan Carlos Izpisua Belmonte +23 more
TL;DR: It is reported that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.
Journal ArticleDOI
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Hsin-Kai Liao,Fumiyuki Hatanaka,Toshikazu Araoka,Toshikazu Araoka,Pradeep Reddy,Min-Zu Wu,Min-Zu Wu,Yinghui Sui,Takayoshi Yamauchi,Takayoshi Yamauchi,Masahiro Sakurai,David D. O'Keefe,Estrella Núñez-Delicado,Pedro Guillen,Josep M. Campistol,Cheng-Jang Wu,Li-Fan Lu,Concepcion Rodriguez Esteban,Juan Carlos Izpisua Belmonte +18 more
TL;DR: It is demonstrated that CRISPR/Cas9-mediated target gene activation can be achieved in vivo, leading to measurable phenotypes and amelioration of disease symptoms, and establishes new avenues for developing targeted epigenetic therapies against human diseases.
Journal ArticleDOI
3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors.
Zhongwei Li,Toshikazu Araoka,Toshikazu Araoka,Jun Wu,Jun Wu,Hsin Kai Liao,Hsin Kai Liao,Mo Li,Marta Lazo,Bing Zhou,Yinghui Sui,Min-Zu Wu,Isao Tamura,Yun Xia,Ergin Beyret,Taiji Matsusaka,Ira Pastan,Concepcion Rodriguez Esteban,Isabel Guillen,Pedro Guillen,Josep M. Campistol,Juan Carlos Izpisua Belmonte +21 more
TL;DR: It is shown that with appropriate 3D culture conditions, it is possible to support long-term expansion of primary mouse and human fetal NPCs as well as NPCs derived from human induced pluripotent stem cells (iPSCs), providing a technological platform for studying human nephrogenesis, modeling and diagnosing renal diseases, and drug discovery.
Journal ArticleDOI
Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice
Takafumi Toyohara,Shin Ichi Mae,Shin Ichi Sueta,Tatsuyuki Inoue,Yukiko Yamagishi,Tatsuya Kawamoto,Tomoko Kasahara,Azusa Hoshina,Taro Toyoda,Hiromi Tanaka,Toshikazu Araoka,Aiko Sato-Otsubo,Kazutoshi Takahashi,Yasunori Sato,Noboru Yamaji,Seishi Ogawa,Shinya Yamanaka,Kenji Osafune +17 more
TL;DR: It is found that renal subcapsular transplantation of hiPSC‐derived renal progenitors ameliorated the AKI in mice induced by ischemia/reperfusion injury, significantly suppressing the elevation of blood urea nitrogen and serum creatinine levels and attenuating histopathological changes.