Tongjian Cai

TL;DR: It is demonstrated that Mn activates the NLRP3-CASP1 inflammasome pathway in the hippocampus of mice and BV2 cells by triggering autophagy-lysosomal dysfunction, leading to hippocampal-dependent impairment in learning and memory, which is associated with the pathogenesis of Alzheimer disease.

TL;DR: Results suggested that dopaminergic neurons could be damaged by manganese neurotoxicity, and that the activated microglial cells and their associated activation products played an important role in this neurodegenerative process.

TL;DR: It is demonstrated that Pb can cause abnormally hyperphosphorylation of tau and accumulation of α-synuclein, and these can induce hippocampal injury and the ability of learning and memory damage, the first evidence showing the novel role of autophagy in the neurotoxicity of Pb.

TL;DR: Results demonstrate, for the first time, that autophagy may play a protective role against Mn-induced neuronal damage, whilst dysregulation of autophagic at later phases may mediate DAergic neurodegeneration.

TL;DR: The authors' ongoing experiences with case competitions suggest that longstanding traditions of academic globalhealth programmes that are located exclusively in public health schools might need to give way to more integrated instruction that incorporates competencies and training from several disciplines.