Torsten K. Roepke

TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.

TL;DR: It is demonstrated that KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function.

TL;DR: It is shown that the potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone–stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis.

TL;DR: The authors showed that colonic CaSR signaling stimulates the degradation of cyclic nucleotides by phosphodiesterases and described the ability of receptor activation to reverse the fluid and electrolyte secretory actions of cAMP-and cGMP-generating secretagogues, including cholera toxin and heat stable Escherichia coli enterotoxin STa.

TL;DR: Targeted disruption of kcne2 has revealed a novel cardiac partner for MiRP1, a novel role for MiRPs in α subunit targeting in vivo, and a role forMiRP1 in murine ventricular repolarization with parallels to that proposed for the human heart.