Lei Yang

TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.

TL;DR: The identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ is reported, which provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.

TL;DR: In vitro-derived cardiomyocytes from LEOPARD syndrome iPSCs are larger, have a higher degree of sarcomeric organization and preferential localization of NFATC4 in the nucleus when compared with cardiomeocytes derived from human embryonic stem cells or wild-type iPSC derived from a healthy brother of one of the LEopARD syndrome patients, which correlate with a potential hypertrophic state.

TL;DR: It is shown that the seeded multipotential cardiovascular progenitor cells migrate, proliferate and differentiate in situ into cardiomyocytes, smooth muscle cells and endothelial cells to reconstruct the decellularized hearts.

TL;DR: The studies demonstrate that AChE is potentially a marker and a regulator of apoptosis and that blocking the expression of A ChE with antisense inhibited apoptosis.