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Geoffrey W. Abbott
Researcher at University of California, Irvine
Publications - 151
Citations - 7593
Geoffrey W. Abbott is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Potassium channel & KCNE2. The author has an hindex of 36, co-authored 138 publications receiving 6863 citations. Previous affiliations of Geoffrey W. Abbott include Yale University & Cornell University.
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Journal ArticleDOI
Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
Lei Yang,Mark H. Soonpaa,Eric Adler,Torsten K. Roepke,Steven J. Kattman,Marion Kennedy,Els Henckaerts,Kristina Bonham,Geoffrey W. Abbott,R. Michael Linden,R. Michael Linden,Loren J. Field,Gordon Keller,Gordon Keller +13 more
TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.
Journal ArticleDOI
MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
Geoffrey W. Abbott,Federico Sesti,Igor Splawski,Marianne E. Buck,Michael H. Lehmann,Katherine W Timothy,Mark T. Keating,Steve A.N. Goldstein +7 more
TL;DR: A mechanism for acquired arrhythmia is revealed: genetically based reduction in potassium currents that remains clinically silent until combined with additional stressors.
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A common polymorphism associated with antibiotic-induced cardiac arrhythmia
Federico Sesti,Geoffrey W. Abbott,Jian Wei,Katherine T. Murray,Sanjeev Saksena,Peter J. Schwartz,Silvia G. Priori,Dan M. Roden,Alfred L. George,Steve A.N. Goldstein +9 more
TL;DR: It is concluded that allelic variants of MiRP1 contribute to a significant fraction of cases of drug-induced LQTS through multiple mechanisms and that common sequence variations that increase the risk of life-threatening drug reactions can be clinically silent before drug exposure.
Journal ArticleDOI
MiRP2 Forms Potassium Channels in Skeletal Muscle with Kv3.4 and Is Associated with Periodic Paralysis
Geoffrey W. Abbott,Margaret H. Butler,Saïd Bendahhou,Marinos C. Dalakas,Louis J. Ptáček,Steve A.N. Goldstein +5 more
TL;DR: The subthreshold, voltage-gated potassium channel of skeletal muscle is shown to contain MinK-related peptide 2 (MiRP2) and the pore-forming subunit Kv3.4, which operates with a classical potassium channel subunit to govern skeletal muscle function and pathophysiology.
Journal ArticleDOI
The MinK-related peptides.
TL;DR: The ubiquity of MiRP expression and their promiscuous association with Kv alpha subunits suggest a prominent role for MiRPs in channel dependent systems.