E
Els Henckaerts
Researcher at King's College London
Publications - 38
Citations - 2316
Els Henckaerts is an academic researcher from King's College London. The author has contributed to research in topics: Adeno-associated virus & Progenitor cell. The author has an hindex of 14, co-authored 36 publications receiving 2160 citations. Previous affiliations of Els Henckaerts include Icahn School of Medicine at Mount Sinai & University of Antwerp.
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Journal ArticleDOI
Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
Lei Yang,Mark H. Soonpaa,Eric Adler,Torsten K. Roepke,Steven J. Kattman,Marion Kennedy,Els Henckaerts,Kristina Bonham,Geoffrey W. Abbott,R. Michael Linden,R. Michael Linden,Loren J. Field,Gordon Keller,Gordon Keller +13 more
TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.
Journal ArticleDOI
Generation of dendritic cells from bone marrow progenitors using gm-csf, tnf-alpha, and additional cytokines: antagonistic effects of il-4 and ifn-gamma and selective involvement of tnf-alpha receptor-1
Filip Lardon,H.-W. Snoeck,Zwi N. Berneman,Viggo Van Tendeloo,Griet Nijs,Marc Lenjou,Els Henckaerts,C. J. Boeckxtaens,Peter Vandenabeele,Luc Kestens,D. R. Van Bockstaele,Guido Vanham +11 more
TL;DR: It is concluded that the expansion of DC from BM progenitors could most effectively be enhanced in a two‐stage culture assay using SCF, GM‐CSF, TNF‐α and IL‐4 and that IFN‐γ counteracts some of the effects of IL‐ 4 in DC generation.
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Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors.
Cédric Boucherie,Sayandip Mukherjee,Els Henckaerts,Adrian J. Thrasher,Jane C. Sowden,Robin R. Ali +5 more
TL;DR: It is reported that formation of a transient self‐organized neuroepithelium from human embryonic stem cells cultured together with extracellular matrix is sufficient to induce a rapid conversion into retinal progenitors in 5 days.
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Quantitative Trait Analysis Reveals Transforming Growth Factor-β2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function
TL;DR: Genetically determined variation in the proliferation of lin−Sca1++kit+ (LSK) primitive hematopoietic progenitor cells in response to transforming growth factor-β (TGF-β) 2 suggests that TGF- β2 can act cell autonomously and is important for HSCs that have undergone replicative stress.
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A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
Julie Tordo,Claire O'Leary,André S L M Antunes,Nuria Palomar,Patrick Aldrin-Kirk,Mark Basche,Antonette Bennett,Zelpha D'Souza,Hélène F.E. Gleitz,Annie Godwin,Rebecca J. Holley,Helen Parker,Ai Yin Liao,Paul Rouse,Amir Saam Youshani,Larbi Dridi,Carla Martins,Thierry Levade,Kevin B. Stacey,Daniel M. Davis,Adam Dyer,Nathalie Clement,Tomas Björklund,Robin R. Ali,Mavis Agbandje-McKenna,Ahad A. Rahim,Alexey V. Pshezhetsky,Simon N. Waddington,Simon N. Waddington,R. Michael Linden,Brian W. Bigger,Els Henckaerts +31 more
TL;DR: A novel AAV gene therapy vector, AAV-TT, is presented, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables unprecedented correction of a lysosomal transmembrane enzyme deficiency.