Showing papers in "Blood in 1983"

TL;DR: On a passe en revue les diverses indications cliniques, histologiques, pharmacologiques and physiopathologiques confirmant l'existence d'une relation etroite entre les anomalies de the coagulation du sang and la biologie du cancer.

TL;DR: A review critically examines the inducers of leukemic cell differentiation and their potential therapeutic importance in patients with acute myelogenous leukemia.

TL;DR: This article showed that depletion of T lymphocytes by this technique can abrogate the potential of histoincompatible marrow grafts to induce lethal GVHD without limiting immunologic reconstitution.

TL;DR: Immunoprecipitation and affinity chromatography studies indicated that the antibody binds to glycoprotein lb at a site contained on the externally oriented portion of the GPIb alpha chain (glycocalicin).

TL;DR: A new rat monoclonal antibody, CAMPATH 1, which is suitable for depleting lymphocytes from human marrow grafts, and an IgM that fixes human complement is described, which could potentially be applied to other experimental and clinical situations where depletion of lymphoid cells is required.

TL;DR: A significant trend was observed relating the presence of lineage infidelity and failure of remission-induction and the data are interpreted as support for abnormal gene expression in leukemia.

TL;DR: Application of this approach to a variety of pathologic blood samples showed that various hematologic disorders can be characterized by the shape of this profile and the position of specific features of the profile along the osmolality axis.

TL;DR: It is concluded that high-dose cytosine arabinoside in the maximally tolerated regimen of 3 g/sq m every 12 hr for 6 days has substantial antileukemic activity in patients refractory to standard therapy.

TL;DR: Hematologic remission of the disease was obtained in 5 patients and enlarged spleens decreased in 3 of 3 patients maintained on HuIFN-alpha, 3 X 10(6) U daily or every other day, for 6-35+ wk.

TL;DR: The development of a nontoxic and reproducible method for detaching the adherent layer and making it into a single-cell suspension suitable for characterization by colony assays was found to provide an appropriate methodology and emphasize the importance of assessing the progenitor content of the adherence layer of long-term human marrow cultures.

TL;DR: Four patients developed anti-mouse immunoglobulin (Ig) antibodies, and in three patients, this was responsible for tumor escape from therapy, and a small but significant component was found to be antiidiotype.

TL;DR: The view is advanced that differentiation continues in these diseases, but new programs are assembled abnormally but with normal components.

TL;DR: High-dose intravenous gammaglobulin (IVIgG) was given to 12 children and adults with chronic idiopathic thrombocytopenic purpura to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives.

TL;DR: The selective toxicity of CdA toward both dividing and resting lymphocytes may render the drug useful as an immunosuppressive or antileukemic agent.

TL;DR: A series of monoclonal antibodies that reacts with myeloids-associated determinants on committed myeloid stem cells and their progeny are generated and potential applications of these antibodies to studies of normal and malignant hematopoiesis are discussed.

TL;DR: The VAPA protocol continues to offer a promising approach to treatment of AML and thirty-one of 41 patients who completed the regimen remain in remission without maintenance therapy.

TL;DR: The effects of repeated courses of 5-azacytidine in a small group of severely ill patients are investigated to determine whether this drug may have a role in the treatment of patients with sickle cell anemia and beta- thalassemia.

TL;DR: The selectivity of monoclonal antibody J-5 (anti-gp 100, common ALL antigen) for normal and leukemic hemopoietic cells has been investigated and a similar pattern of selective reactivity was observed in a series of leukemia/lymphoma cell lines.

TL;DR: It is suggested that oral retinoic acid may be a useful adjunct in the treatment of APL and induces maturation of leukemic promyelocytes in vitro and suggest that similar maturation is achievable in vivo.

TL;DR: A series of monoclonal antibodies reactive with normal myeloid cells at different stages of differentiation were used to characterize the leukemic cells of 70 patients with acute myeloblastic leukemia (AML) as discussed by the authors.

TL;DR: The data suggest that a new cytogenetic-clinical subtype of ANLL defined by the del(16)(q22) is identified, and both patients who survived initial treatment remain in complete remission at 23+ and 33+ mo.

TL;DR: Proteine C: structure, role de cofacteurs et de la surface des cellules endotheliales dans son activation, proprietes anticoagulantes de la proteine C activee, deficience et thrombose, preuve de l'activation de proteine au cours de la coagulation as mentioned in this paper.

TL;DR: It is postulate that the acquired hypoprothrombinemia in these two patients and in other reported patients with the acquired Hypoprothombinemi-lupus anticoagulant syndrome stems from rapid clearance from the circulation of prothrombin antigen-antibody complexes.

TL;DR: Determination of surface antigen phenotype in CML blast crisis thus provides clinically useful information for the structuring of treatment protocols.

TL;DR: Initial treatment for localized lymphomas of unfavorable histology with chemotherapy regimens of proven curative potential in advanced disease is a successful treatment strategy and obviates the need for extensive staging.

TL;DR: Five patients with smoldering adult T-cell leukemia (ATL) who had skin lesions as premonitory symptoms should be distinguished from typical ATL cases for the purposes of prognosis and treatment, based on clinical and pathologic differences.

TL;DR: Results indicate that a high proportion of monoclonal Ig possess antibody activity against actin, which contrasts sharply with the positive reactions found toward all the other antigens tested: only one each for dsDNA, tubulin, thyroglobulin, and myosin, and none against myoglobin, fetuin, album in, and transferrin.

TL;DR: The fact that these patients entered remission relatively slowly and did not suffer marrow aplasia suggests that low-dose ARA-C may function in vivo as it does in vitro, i.e., by inducing differentiation of leukemic blasts.