Trent C. Bjorndahl

TL;DR: New database visualization tools and new data content have been added or enhanced to the HMDB, which includes better spectral viewing tools, more powerful chemical substructure searches, an improved chemical taxonomy and better, more interactive pathway maps.

TL;DR: A comprehensive, quantitative, metabolome-wide characterization of human urine and the identification and annotation of several previously unknown urine metabolites and to substantially enhance the level of metabolome coverage are undertaken.

TL;DR: A unique metabolomic fingerprint was identified of HFpEF that is distinct from that of HFrEF that will help understand its pathophysiology and assist in establishing new biomarkers for its diagnosis.

TL;DR: The structural determinants of type II' beta-turns were probed through a comprehensive CD, NMR, and molecular dynamics analysis of 10 specially designed beta-hairpin peptides and it is demonstrated that backbone heterochirality, which determines equatorial and axial side-chain orientation at the i+1 and i+2 residues oftype II' turns, may account for up to 60% ofType II' Beta-turn stabilization.

TL;DR: It is found that acid-induced PrP(β) oligomers could be converted to fibrils without the use of chaotropic denaturants, and this finding represents one of the first examples wherein physiologically accessible conditions were used to achieve PrP conversion and fibril formation.