T
Triparna Sen
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 82
Citations - 3287
Triparna Sen is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Cancer research. The author has an hindex of 25, co-authored 57 publications receiving 1709 citations. Previous affiliations of Triparna Sen include Washington University in St. Louis & National Cancer Research Institute.
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Journal ArticleDOI
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Marcel A. Dammert,Johannes Brägelmann,Rachelle R. Olsen,Stefanie Böhm,Niloufar Monhasery,Christopher P. Whitney,Milind D. Chalishazar,Hannah L. Tumbrink,Matthew R. Guthrie,Sebastian Klein,Abbie S. Ireland,Jeremy Ryan,Anna Schmitt,Annika Marx,Luka Ozretić,Roberta Castiglione,Carina Lorenz,Ron D. Jachimowicz,Elmar Wolf,Roman K. Thomas,John T. Poirier,Reinhard Büttner,Triparna Sen,Lauren Averett Byers,H. Christian Reinhardt,Anthony Letai,Trudy G. Oliver,Martin L. Sos +27 more
TL;DR: The authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.
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Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process
Triparna Sen,Amitava Chatterjee +1 more
TL;DR: The study demonstrates the requirement of cross talk between cell matrix adhesion molecules and growth factor receptors to improve biological responses and shows FAK/ERK as the pivotal point of this convergence in human breast carcinoma cell line MDA-MB-231.
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Fibronectin-integrin (α5β1) modulates migration and invasion of murine melanoma cell line B16F10 by involving MMP-9
TL;DR: It is demonstrated that integrin receptor alpha5beta1 and FN interaction induces the invasive potential of B16F10 cells and MMP-9 induction is the downstream effectors in the process.
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Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity
Gargi Maity,Paromita Roy Choudhury,Triparna Sen,Kirat Kumar Ganguly,Hrishikesh Sil,Amitava Chatterjee +5 more
TL;DR: Fibronectin–integrin-mediated signaling and thereby modulation of MMPs expression and activity in human breast cancer cell line, MDA-MB-231 is investigated to enrich fundamental aspects of cancer biology especially role of α5β1 integrin in regulation of M MPs expression andactivity.
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Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7).
TL;DR: The experimental findings clearly showed the inhibition of MMP-2 activity upon ATRA treatment, which may result due to its inhibitory effect on MT1-MMP, EMMPRIN, and upregulation of TIMP-2.