T
Triparna Sen
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 82
Citations - 3287
Triparna Sen is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Cancer research. The author has an hindex of 25, co-authored 57 publications receiving 1709 citations. Previous affiliations of Triparna Sen include Washington University in St. Louis & National Cancer Research Institute.
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Phosphatidylinositol 3-Kinase and NF-κB Involved in Epidermal Growth Factor-Induced Matrix Metalloproteinase-9 Expression
Shuvojit Moulik,Triparna Sen,Anindita Dutta,Aniruddha Banerji,Chinmoy Ghosh,Shamik Das,Amitava Chatterjee +6 more
TL;DR: EGF induced expression of MMP-9 in MDA-MB-231 cells through the NF-κB and PI3-K pathways is investigated to investigate the signaling pathways responsible for epidermal growth factor (EGF)-induced M MP-9 expression.
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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer.
Rebecca Caeser,Christopher H. Hulton,Emily A. Costa,Emily A. Costa,Vidushi Durani,Vidushi Durani,Megan Little,Xiaoping Chen,Sam E. Tischfield,Marina Asher,Faruk Erdem Kombak,Shweta S. Chavan,Nisargbhai S. Shah,Metamia Ciampricotti,Elisa de Stanchina,John T. Poirier,Charles M. Rudin,Triparna Sen +17 more
TL;DR: In this paper, the role of mitogen-activated protein kinase (MAPK) pathway and how it interacts with other signaling pathways in small cell lung cancer (SCLC) was elucidated.
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Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts
Rebecca Caeser,Jacklynn V. Egger,Shweta Chavan,Nicholas D. Socci,Caitlin Byrne Jones,Faruk Erdem Kombak,Marina Asher,Michael H.A. Roehrl,Nisargbhai S. Shah,Viola Allaj,P. Manoj,Sam E. Tischfield,Amanda Kulick,Maximiliano Meneses,Christine A. Iacobuzio-Donahue,Wei Li,Umesh Bhanot,Marina K Baine,Natasha Rekhtman,Travis J. Hollmann,Elisa de Stanchina,John T. Poirier,Charles M. Rudin,Triparna Sen +23 more
TL;DR: In this article , the authors presented a resource of 46 extensively annotated PDX/CDX models derived from 33 patients with small cell lung cancer (SCLC) using targeted tumor next-generation sequencing, RNA-sequencing, and immunohistochemistry to deconvolute the mutational landscapes, global expression profiles, and molecular subtypes of these SCLC models.
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Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer exhibits antitumor efficacy with low toxicity.
Kathryn M. Tully,Salomon Tendler,Lukas M. Carter,Sai Kiran Sharma,Zachary Samuels,Komal Mandleywala,Joshua A. Korsen,Avelyn Mae Delos Reyes,Alessandra Piersigilli,William D. Travis,Triparna Sen,Nagavarakishore Pillarsetty,John T. Poirier,Charles M. Rudin,Jason S. Lewis +14 more
TL;DR: Together, the compelling antitumor efficacy, pathologic complete responses, and mild and transient toxicity profile demonstrate strong potential for clinical translation of [177Lu]Lu-DTPA-CHX-A"-SC16.
Posted ContentDOI
Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancer
Joseph M. Chan,Álvaro Quintanal-Villalonga,Vianne R. Gao,Yubin Xie,Viola Allaj,Ojasvi Chaudhary,Ignas Masilionis,Jacklynn V. Egger,Andrew Chow,Thomas Walle,Marissa Mattar,Dig Vk Yarlagadda,James L. Wang,Fathema Uddin,Michael Offin,Metamia Ciampricotti,Umesh Bhanot,W. Victoria Lai,Matthew J. Bott,David R. Jones,Arvin Ruiz,Travis J. Hollmann,John T. Poirier,Tal Nawy,Linas Mazutis,Triparna Sen,Triparna Sen,Dana Pe'er,Charles M. Rudin,Charles M. Rudin +29 more
TL;DR: The single-cell SCLC atlas reveals tumor diversity exceeding lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes, and a PLCG2-high subclone is found that recurs across subtypes and predicts worse overall survival, suggesting possible tumor-immune coordination to promote metastasis.