T
Tsunehiro Aki
Researcher at Hiroshima University
Publications - 128
Citations - 3221
Tsunehiro Aki is an academic researcher from Hiroshima University. The author has contributed to research in topics: Polyunsaturated fatty acid & Fatty acid. The author has an hindex of 30, co-authored 123 publications receiving 2940 citations. Previous affiliations of Tsunehiro Aki include National Institutes of Health & Laboratory of Molecular Biology.
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Journal ArticleDOI
Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase.
Tsunehiro Aki,Yayoi Shimada,Katsuya Inagaki,Hirofumi Higashimoto,Seiji Kawamoto,Seiko Shigeta,Kazuhisa Ono,Osamu Suzuki +7 more
TL;DR: Results indicate that the protein encoded by the rat cDNA is Δ-6 fatty acid desaturase, and the first 17 amino acids corresponding to the coding region 97-147 of the clone are not required to function in yeast.
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Repressor induced site‐specific binding of HU for transcriptional regulation
Tsunehiro Aki,Sankar Adhya +1 more
TL;DR: It is proposed that HU, in concert with GalR, forms a specific nucleoprotein higher order complex containing a DNA loop and deforms the promoter to make the latter inactive for transcription initiation while remaining sensitive to inducer.
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Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae.
Tsunehiro Aki,Takeshi Kodama,Akihiro Fujikawa,Keisuke Miura,Seiko Shigeta,Takeshi Wada,Toshihiko Jyo,Yoshikatsu Murooka,Satoru Oka,Kazuhisa Ono +9 more
TL;DR: In this article, a new allergen complementary DNA (cDNA) clone was isolated from a D. farinae protein cDNA library, which revealed significant homology with tropomyosins conserved in a wide range of animals.
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Thraustochytrid as a potential source of carotenoids
Tsunehiro Aki,Kazutaka Hachida,Megumi Yoshinaga,Yuko Katai,Takashi Yamasaki,Seiji Kawamoto,Toshihide Kakizono,Takashi Maoka,Seiko Shigeta,Osamu Suzuki,Kazuhisa Ono +10 more
TL;DR: It is described here that thraustochytrid strain KH105, isolated as a DHA producer, also accumulates significant levels of β-carotene and xanthophylls including canthaxanthin and astaxanthIn, which is considered to be a promising source of xanthopylls as well as DHA for use in the food industry.
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Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase.
Hyon E. Choy,Seong Weon Park,Tsunehiro Aki,Pradip Parrack,N. Fujita,Akira Ishihama,Sankar Adhya +6 more
TL;DR: It is proposed that Gal and Lac repressors inhibit or stimulate transcription initiation by disabling or stimulating RNA polymerase activity at a post‐binding step by directly or indirectly altering the C‐terminal alpha domain to an unfavorable state at P1 or a more favorable state atP2, respectively.