T
Tze-Peng Lim
Researcher at Singapore General Hospital
Publications - 46
Citations - 1164
Tze-Peng Lim is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Polymyxin B & Acinetobacter baumannii. The author has an hindex of 18, co-authored 42 publications receiving 991 citations. Previous affiliations of Tze-Peng Lim include National University of Health Sciences & National University of Singapore.
Papers
More filters
Journal ArticleDOI
Antibacterial and antifouling catheter coatings using surface grafted PEG-b-cationic polycarbonate diblock copolymers.
Xin Ding,Chuan Yang,Tze-Peng Lim,Tze-Peng Lim,Li Yang Hsu,Amanda C. Engler,James L. Hedrick,Yi Yan Yang +7 more
TL;DR: Polymer coatings with the optimal polymer composition possessed significantly higher antifouling activity than PEG coating, and scanning electron microscopic studies showed that the polymer coating inhibited S. aureus biofilm formation over a period of 7 days.
Journal ArticleDOI
Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections
Andrea L. Kwa,Tze-Peng Lim,Jenny G. Low,JingGuo Hou,Asok Kurup,Randall A. Prince,Vincent H. Tam +6 more
TL;DR: This is the 1st case series to date in which the pharmacokinetics of polymyxin B1 after intravenous administration are described, and the results in conjunction with pharmacodynamic and susceptibility surveillance studies could facilitate an approach to the design of optimal dosing regimens.
Journal ArticleDOI
In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore.
Tze-Peng Lim,Thean Yen Tan,Winnie Lee,Suranthran Sasikala,Thuan Tong Tan,Li Yang Hsu,Andrea L. Kwa +6 more
TL;DR: It is demonstrated that in-vitro synergy of antibiotic combinations in CR AB may be strain dependant, which may guide us in choosing a pre-emptive therapy for CR AB infections and warrants further investigations.
Journal ArticleDOI
Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.
Tze-Peng Lim,Winnie Lee,Thean Yen Tan,Suranthran Sasikala,Jocelyn Qi-Min Teo,Li Yang Hsu,Thuan Tong Tan,Nur Syahidah,Andrea L. Kwa +8 more
TL;DR: Bactericidal activity with sustained killing effect of ≥99.9% is critical for eradicating XDR-PA infections, especially in immunocompromised hosts, demonstrating that at least 3 antibiotics are required in combination and that efficacy is strain dependant.
Journal ArticleDOI
Pharmacodynamic Modeling of Aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: Identifying Dosing Regimens To Suppress Resistance Development
TL;DR: The mathematical model was reasonable in predicting extended bacterial responses to various aminoglycoside exposures qualitatively, based on limited input data, and appears promising as a decision support tool for dosing regimen selection for antimicrobial agents.