J
Jenny G. Low
Researcher at Singapore General Hospital
Publications - 140
Citations - 9375
Jenny G. Low is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Vaccination & Dengue virus. The author has an hindex of 36, co-authored 122 publications receiving 6101 citations. Previous affiliations of Jenny G. Low include National University of Singapore & Tan Tock Seng Hospital.
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Journal ArticleDOI
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.
Barnaby Edward Young,Sean Wei Xiang Ong,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,Seow Yen Tan,Jiashen Loh,Oon Tek Ng,Kalisvar Marimuthu,Li Wei Ang,Tze Minn Mak,Sok Kiang Lau,Danielle E. Anderson,Kian Sing Chan,Thean Yen Tan,Thean Yen Tan,Tong Yong Ng,Lin Cui,Zubaidah Said,Lalitha Kurupatham,Mark I-Cheng Chen,Monica Chan,Shawn Vasoo,Lin-Fa Wang,Boon Huan Tan,Raymond T. P. Lin,Vernon J. Lee,Yee Sin Leo,David C. Lye +29 more
TL;DR: Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection and some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent.
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SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
Journal ArticleDOI
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.
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Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Wan Ni Chia,Feng Zhu,Sean Wei Xiang Ong,Barnaby Edward Young,Barnaby Edward Young,Siew-Wai Fong,Nina Le Bert,Chee Wah Tan,Charles Tiu,Jinyan Zhang,Seow Yen Tan,Surinder Pada,Yi Hao Chan,Christine Y.L. Tham,Kamini Kunasegaran,Mark I-Cheng Chen,Jenny G. Low,Jenny G. Low,Yee Sin Leo,Laurent Rénia,Antonio Bertoletti,Lisa F. P. Ng,David C. Lye,Lin-Fa Wang +23 more
TL;DR: In this paper, the authors investigated the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.
Journal ArticleDOI
A Dynamic Immune Response Shapes COVID-19 Progression.
Eugenia Z. Ong,Yvonne Fu Zi Chan,Wan Ying Leong,Natalie Mei Ying Lee,Shirin Kalimuddin,Shirin Kalimuddin,Salahudeen Mohamed Haja Mohideen,Kian Sing Chan,Anthony T. Tan,Antonio Bertoletti,Eng Eong Ooi,Eng Eong Ooi,Jenny G. Low,Jenny G. Low +13 more
TL;DR: In this article, the authors conducted daily transcriptomic profiling of three COVID-19 cases and found that the early immune response in SARS-coronavirus-2 (SARS-CoV2) infection is highly dynamic.