Ulrich Bogdahn

TL;DR: Evidence is provided that long-term continuous infusion of highly purified antisense phosphorothioate oligodeoxynucleotides (S-ODN) into brain parenchyma is well tolerated and thus highly suitable for in vivo application, and proves the suitability of AP 12009 for local administration in brain tumor patients from the point of view of toxicology.

TL;DR: It is shown that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro, and that the molecular subtype of CSCs T GF-beta-dependently contributes to the degree of immune infiltration.

TL;DR: It is found that Smad 7 is up-regulated in peripheral CD4+ cells from patients with multiple sclerosis during relapse but not remission, and that expression of Smad7 strongly correlates with T-bet, a transcription factor defining T helper 1 responses.

TL;DR: Investigating the diagnostic accuracy and time frames for neurological and transcranial color-coded sonography assessments in a prehospital ‘911’ emergency stroke situation by using portable duplex ultrasound devices to visualize the bilateral middle cerebral arteries concluded that prehospital diagnosis of MCA occlusion in stroke patients is feasible with or without administration of a microbubble contrast agent.

TL;DR: Preliminary dataicate that TCCS and particularly contrast‐enhanced T CCS permit identification and blood flow measurements within the deep and occasionally, the superficial venous system.