A
Alexander Mildner
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 70
Citations - 15247
Alexander Mildner is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Monocyte & Microglia. The author has an hindex of 39, co-authored 63 publications receiving 12925 citations. Previous affiliations of Alexander Mildner include University of Göttingen & Weizmann Institute of Science.
Papers
More filters
Journal ArticleDOI
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis (vol 38, pg 79, 2013)
Simon Yona,K-W Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,A Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,S Jung +14 more
TL;DR: In this paper, a fate-mapping study of the macrophage compartment is presented, taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression.
Journal ArticleDOI
Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
Diego Jaitin,Ephraim Kenigsberg,Hadas Keren-Shaul,Naama Elefant,Franziska Paul,Irina Zaretsky,Alexander Mildner,Nadav Cohen,Steffen Jung,Amos Tanay,Ido Amit +10 more
TL;DR: An automated massively parallel single-cell RNA sequencing approach for analyzing in vivo transcriptional states in thousands of single cells is introduced and provides the ability to perform a bottom-up characterization of in vivo cell-type landscapes independent of cell markers or prior knowledge.
Journal ArticleDOI
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Alexander Mildner,Hauke Schmidt,Mirko Nitsche,Doron Merkler,Uwe-Karsten Hanisch,Matthias Mack,Mathias Heikenwalder,Wolfgang Brück,Josef Priller,Marco Prinz +9 more
TL;DR: Using a panel of bone marrow chimeric and adoptive transfer experiments, it is found that circulating Ly-6ChiCCR2+ monocytes were preferentially recruited to the lesioned brain and differentiated into microglia.
Journal ArticleDOI
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Franziska Paul,Yaâara Arkin,Amir Giladi,Diego Adhemar Jaitin,Ephraim Kenigsberg,Hadas Keren-Shaul,Deborah R. Winter,David Lara-Astiaso,Meital Gury,Assaf Weiner,Eyal David,Nadav Cohen,Felicia Kathrine Bratt Lauridsen,Simon Haas,Andreas Schlitzer,Andreas Schlitzer,Alexander Mildner,Florent Ginhoux,Steffen Jung,Andreas Trumpp,Bo Torben Porse,Amos Tanay,Ido Amit +22 more
TL;DR: This work comprehensively map myeloid progenitor subpopulations by transcriptional sorting of single cells from the bone marrow, showing unexpected transcriptional priming toward seven differentiation fates but no progenitors with a mixed state.