Ulrich Mahlknecht

TL;DR: The therapeutic strategy could become a new standard of care after autologous stem-cell transplantation; however, prophylactic platelet transfusion should remain the standard for patients with acute myeloid leukaemia.

TL;DR: It is shown here that wogonin, derived from the popular Chinese herb Huang-Qin, attenuates NF-kappaB activity by shifting TNFalpha-induced free radical .O(2)(-) to a more reduced nonradical product, H(2)O( 2), and thereby sensitizes TNF alpha-resistant leukemia cells to TNFAlpha-induced apoptosis.

TL;DR: DNA methylation analysis of blood and bone marrow samples from MDS patients undergoing azacytidine therapy revealed substantial differences in the epigenetic responses of individual patients, and detailed insight into drug-induced demethylation responses is provided.

TL;DR: Roc derivatives may be promising candidates for the development of new drugs against hematologic malignancies, and Investigation of the molecular mechanisms by which Roc kills tumors revealed that it induces a consistent activation of the stress‐response mitogen‐activated protein kinase (MAPK) p38 accompanied with a long‐term suppression of the survival MAPK extracellular signal‐regulated kinase.

TL;DR: All ageing phenomena—tissue deterioration, cancer and propensity to infections—can be interpreted as signs of ageing at the level of somatic stem cells.