U
Ulrich Schäfer
Researcher at Saarland University
Publications - 172
Citations - 5863
Ulrich Schäfer is an academic researcher from Saarland University. The author has contributed to research in topics: Aortic valve stenosis & Heart valve. The author has an hindex of 36, co-authored 162 publications receiving 5068 citations. Previous affiliations of Ulrich Schäfer include German Research Centre for Artificial Intelligence.
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Journal ArticleDOI
Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa
TL;DR: The use of submicron-sized carriers holds promise for the targeted delivery of drugs to the inflamed colonic mucosal areas in inflammatory bowel disease.
Journal Article
Biodegradable Nanoparticles for Targeted Drug Delivery in Treatment of Inflammatory Bowel Disease
Alf Lamprecht,Nathalie Ubrich,Hiromitsu Yamamoto,Ulrich Schäfer,Hirofumi Takeuchi,Philippe Maincent,Yoshiaki Kawashima,Claus-Michael Lehr +7 more
TL;DR: The use of nanoparticles for targeted oral drug delivery to the inflamed gut tissue in inflammatory bowel disease was examined in this article, where Rolipram, an anti-inflammatory model drug, was incorporated within poly(lactic-coglycolic acid) nanoparticles, which were administered once a day orally for five consecutive days.
Journal ArticleDOI
Selective follicular targeting by modification of the particle sizes
Alexa Patzelt,Heike Richter,Fanny Knorr,Ulrich Schäfer,Claus-Michael Lehr,Lars Dähne,Wolfram Sterry,Juergen Lademann +7 more
TL;DR: By varying the particle size, different sites within the porcine hair follicle can be targeted selectively, and the situation can be expected to be similar due to a similar size ratio of the hair follicles.
Journal ArticleDOI
The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study:
Monika Schäfer-Korting,Udo Bock,Walter Diembeck,Hans-Jürgen Düsing,A.O. Gamer,Eleonore Haltner-Ukomadu,Christine Hoffmann,Monika Kaca,Hennicke Kamp,Silke Kersen,Manfred Kietzmann,Hans Christian Korting,Hans-Udo Krächter,Claus-Michael Lehr,Manfred Liebsch,Annette Mehling,Christel C. Müller-Goymann,Frank Netzlaff,Frank Niedorf,M.K. Rübbelke,Ulrich Schäfer,Elisabeth Schmidt,S. Schreiber,Horst Spielmann,Alexander Vuia,Michaela Weimer +25 more
TL;DR: The RHE models, EPISKIN, EpiDerm and SkinEthic, are appropriate alternatives to human and pig skin, for the in vitro assessment of the permeation and penetration of substances when applied as aqueous solutions.
Journal ArticleDOI
Cardiac mast cell–derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
Christina J. Mackins,Seiichiro Kano,Nahid Seyedi,Ulrich Schäfer,Alicia C. Reid,Takuji Machida,Randi B. Silver,Roberto Levi +7 more
TL;DR: Mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion and may be a useful therapeutic target for hyperadrenergic dysfunctions, such as arrhythmias, sudden cardiac death, myocardial ischemIA, and congestive heart failure.