Ulrich T. Hacker

TL;DR: Autophagy is identified as a pivotal cell response determining the efficiency of AAVs intracellular processing in hepatocytes and thus the outcome of liver‐directed gene therapy using AAV vectors and it is shown in a proof‐of‐principle study how this virus–host interaction can be employed to enhance efficacy of this vector system.

TL;DR: An up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy are provided and the perspectives for the future translation of these pre-clinical approaches into the clinic are discussed.

TL;DR: A capsid variant, AAV-VEC, is identified, which outperformed the parental serotype as well as first-generation targeting vectors in EC transduction and significantly expands the AAV tool kit for a wide range of applications targeting EC.

TL;DR: In this article, the authors discuss the consequences of inducing pyroptosis and necroptosis in the tumor microenvironment and the perspectives they may offer to increase the immunogenicity of the so-called cold tumors and to stimulate effective anti-tumor immune responses.

TL;DR: Gastric cancer is a leading cause of cancer death worldwide as mentioned in this paper, and molecular characterization of gastric adenocarcinomas by the TCGA Consortium and ACRG has resulted in the definition of distinct molecular subtypes.