J
Julie Lucifora
Researcher at University of Lyon
Publications - 87
Citations - 3629
Julie Lucifora is an academic researcher from University of Lyon. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 25, co-authored 71 publications receiving 2985 citations. Previous affiliations of Julie Lucifora include French Institute of Health and Medical Research & Technische Universität München.
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Journal ArticleDOI
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Julie Lucifora,Yuchen Xia,Florian Reisinger,Ke Zhang,Daniela Stadler,Xiaoming Cheng,Martin F. Sprinzl,Herwig Koppensteiner,Zuzanna Makowska,Tassilo Volz,Caroline Remouchamps,Wen Min Chou,Wolfgang E. Thasler,Norbert Hüser,David Durantel,T. Jake Liang,Carsten Münk,Markus H. Heim,Jeffrey L. Browning,Emmanuel Dejardin,Maura Dandri,Michael Schindler,Mathias Heikenwalder,Ulrike Protzer +23 more
TL;DR: It is described how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and proposed lymphotoxin-β receptor activation as a therapeutic alternative and the development of new therapeutics that, in combination with existing antivirals, may cure hepatitis B.
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Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Julie Lucifora,Silke Arzberger,David Durantel,David Durantel,David Durantel,Laura Belloni,Laura Belloni,Michel Strubin,Massimo Levrero,Massimo Levrero,Fabien Zoulim,Fabien Zoulim,Fabien Zoulim,Olivier Hantz,Olivier Hantz,Ulrike Protzer +15 more
TL;DR: It is demonstrated that HBx is required to initiate and maintain HBV replication and highlight HBx as the key regulator during the natural infection process.
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Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Yuchen Xia,Daniela Stadler,Julie Lucifora,Florian Reisinger,Dennis Webb,Marianna Hösel,Thomas Michler,Karin Wisskirchen,Xiaoming Cheng,Ke Zhang,Wen-Min Chou,Jochen M. Wettengel,Antje Malo,Felix Bohne,Dieter Hoffmann,Florian Eyer,Robert Thimme,Christine S. Falk,Wolfgang E. Thasler,Mathias Heikenwalder,Ulrike Protzer +20 more
TL;DR: IFNγ and TNF-α, produced by T cells, reduce levels of HBV ccc DNA in hepatocytes by inducing deamination and subsequent cccDNA decay.
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Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure
Mirjam B. Zeisel,Julie Lucifora,William S. Mason,Camille Sureau,Jürgen Beck,Massimo Levrero,Michael Kann,Percy A. Knolle,Monsef Benkirane,David Durantel,Marie Michel,Brigitte Autran,François-Loïc Cosset,Helene Strick-Marchand,Christian Trepo,Jia-Horng Kao,Fabrice Carrat,Karine Lacombe,Raymond F. Schinazi,Françoise Barré-Sinoussi,Jean François Delfraissy,Fabien Zoulim +21 more
TL;DR: This review summarises the current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.
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Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells
Isabelle Vincent,Isabelle Vincent,Claudia Zannetti,Claudia Zannetti,Julie Lucifora,Helene Norder,Ulrike Protzer,Pierre Hainaut,Fabien Zoulim,Fabien Zoulim,Massimo Tommasino,Christian Trepo,Christian Trepo,Uzma Hasan,Uzma Hasan,Isabelle Chemin,Isabelle Chemin +16 more
TL;DR: HBV has developed several escape mechanisms to avoid TLR9 activation in both pDCs and B lymphocytes, which may in turn contribute to the establishment and/or persistence of chronic infection.