Alexander Gluschko

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is demonstrated that L.m. infection of macrophages in vivo exclusively evokes LC3-associated phagocytosis (LAP), but not canonical autophagy, and that targeting of L. m.

TL;DR: In this article, the mtROS induced intermolecular covalent linkage of NEMO through disulfide bonds formed by Cys 54 and Cys 347, which was essential for activation of the IKK complex and subsequent signaling through the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and NF-κB pathways that eventually led to the secretion of proinflammatory cytokines.

TL;DR: The results suggest that acute riboflavin deficiency immediately impairs priming of Nox2, which is of crucial relevance for an effective phagocytic immune response in vivo.

TL;DR: The molecular mechanisms involved in induction and execution of LC3-associated phagocytosis and its crucial role in antimicrobial immunity against bacteria, fungi and parasites are discussed.