Ulrike Boenisch

TL;DR: A Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) is presented and evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans is found.

TL;DR: Deep epigenome mapping with single-cell transcriptomics finds two chromatin-state signatures that track β cell dysfunction in mice and humans: ectopic activation of bivalent Polycomb-silenced domains and loss of expression at an epigenomically unique class of lineage-defining genes.

TL;DR: Investigation of the function of DOT1L in neural stem cells of the cerebral cortex found that loss of H3K79me2 at the Atf4‐ and Ddit3‐promoters appears to mark a point‐of‐no‐return that activates the death program in NSCs.

TL;DR: A novel method for ultra-parallelized high-throughput ChIP-seq that employs barcoding of chromatin within intact nuclei extracted from different sources, for maximal comparability and significant workload reduction.