Anita Öst

TL;DR: A Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) is presented and evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans is found.

TL;DR: In this article, the authors examined insulin signaling in adipocytes from Type 2 diabetes patients, and contrary to findings in animal studies, they observed attenuation of insulin activation of mammalian target of rapamycin (mTOR) in complex with raptor, as a consequence, mTORC1 downstream effects were also affected in T2D: feedback signaling by insulin to signal-mediator insulin receptor substrate-1 was attenuated, mitochondria were impaired and autophagy was strongly upregulated.

TL;DR: In intact primary adipocytes exogenous oleic acid was taken up and directly converted to TG in the plasma membrane, in a novel subclass of caveolae that specifically contains the protein perilipin, demonstrating that specific subclasses of Caveolae carry out specific functions in cell metabolism.

TL;DR: Findings indicate that RBP4 may be released from diabetic adipocytes and act locally to inhibit phosphorylation of IRS1 at serine (307), a phosphor‐ylation site that may integrate nutrient sensing with insulin signaling.

TL;DR: It is reported that human sperm are acutely sensitive to nutrient flux, both in terms of sperm motility and changes in sperm tsRNA, and shared diet-sensitive mechanisms between sperm Motility and the biogenesis of tsRNA are suggested, which provide novel insights about the interplay between nutrition and male reproductive health.