Showing papers in "Osteoarthritis and Cartilage in 2008"

TL;DR: Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.

TL;DR: The OAI knee MRI protocol provides imaging data on multiple articular structures and features relevant to knee OA that will support a broad range of existing and anticipated measurement methods while balancing requirements for high image quality and consistency against the practical considerations of a large multi-center cohort study.

TL;DR: Two distinct pain types were identified - a dull, aching pain which became more constant over time, punctuated increasingly with short episodes of a more intense, often unpredictable, emotionally draining pain and Intermittent intense pain, particularly when unpredictable, had the greatest impact on quality of life.

TL;DR: Based on the use of accepted Rasch-based measurement methods and the compliment of countries, languages and OA severity represented in this study, this seven item short measure of physical function for knee OA is likely generalizable and widely applicable.

TL;DR: Preliminary psychometric testing suggests this OA pain measure is reliable and valid, and Principle components analysis demonstrated factorial complexity.

TL;DR: Results bind more closely the interactions between fat-derived adipokines and articular inflammatory diseases, and suggest that adiponectin is a novel key element in the maintenance of cartilage homeostasis which might be considered as a potential therapeutical target in joint degenerative diseases.

TL;DR: It is hypothesized that migrating contact areas can maintain elevated cartilage interstitial fluid pressurization, thus a low friction coefficient, indefinitely, and confirmed that SF acts as a boundary lubricant.

TL;DR: Standardization of study design and outcome parameters would help to compare different studies evaluating various novel therapeutic concepts and increase the predictive value of preclinical research using animal models and improve the process of developing efficacious therapies.

TL;DR: The recent expert-consensus guidelines for the management of knee and hip osteoarthritis are very insightful and should serve as a powerful clinical tool for many providers, although minimal attention is given to the positive effects of manual physical therapy.

TL;DR: Over 2 years, cartilage defects tend to progress in people with symptomatic OA, with only a small percentage decreasing in severity, and increasing age and increased bone area are risk factors for progression.

TL;DR: Gait kinematics, particularly lateral trunk lean, explain substantial variation in dynamic knee joint load in patients with medial compartment knee osteoarthritis.

TL;DR: An optimal treatment for OA might include targeting both the bone and cartilage compartments, as several cell systems are to be targeted in a safe manner, limited options seem possible.

TL;DR: Six synovial fluid and serum biomarkers were useful in separating early experimental OA from exercise alone but synovIAL fluid CTX1 and serum Col CEQ and CTx1 were not.

TL;DR: A review of the literature on the effects of Nitric oxide on cartilage and chondrocytes as well as some evidence that suggests potential protective effects of NO and/or its derivatives on other cell types are discussed.

TL;DR: There is considerable evidence for a relation between cartilage degeneration and OVX in mature animals and a list of quality criteria for animal models is suggested since standardisation of design and outcome parameters of animal experiments may help to compare different studies and to gain better insight in the role of hormones in the osteoarthritic process.

TL;DR: The molecular and cytokine-based events that drive joint damage in inflammatory arthritides have gradually emerged as pathogenic paradigms in OA, and will be highly relevant to the development of future OA therapeutics.

TL;DR: The increased incidence of knee OA in participants with the MetS was largely explained by increased BMI, and CRP was not associated with incidence of knees or hip OA when possible confounding factors were taken into account.

TL;DR: The French version of KOOS is a valid, reliable, and responsive instrument to capture specific aspects of functional disability affecting quality of life of knee OA patients.

TL;DR: While radiographic approach and study design was associated with JSN, OA definition, cohort composition and study duration were associated with risk of K-L progression, which may inform the design of disease modifying osteoarthritis drug (DMOAD) trials and assist clinicians in optimal timing of OA treatments.

TL;DR: Recent research findings concerning the potential role of VEGF in cartilage are reviewed, focusing in particular on its possible involvement in the pathogenesis of osteoarthritis.

TL;DR: US complements both the clinical examination and radiological imaging by allowing the rheumatologist to recognize not only the bony profile but also to visualize the soft tissues, and is extremely sensitive in the detection of soft tissue changes in the involved joints.

TL;DR: Calcified cartilage is permeable to small solutes and the subchondral circulation may make a significant contribution to the nutrition of deep cartilage in the mature horse.

TL;DR: Treatment of knee OA with glucosamine sulphate for at least 12 months and up to 3 years may prevent TJR in an average follow-up of 5 years after drug discontinuation.

TL;DR: The statistically significant improvement of KOOS symptom and sport parameters together with the consistently higher, though non-statistically significant, improvement of most other parameters demonstrates that Orthokin clearly induces a biological response different from placebo treatment and warrant future investigations into the possible chondroprotective effect of Orthokin.

TL;DR: The results show that oxygen availability has dramatic effects on the differentiation and synthetic potentials of hESCs and may have important implications for the development of strategies to engineer cartilage.

TL;DR: HDAC inhibitors suppressed IL-1-induced NO and PGE(2) synthesis, iNOS and COX-2 expression, as well as proteoglycan degradation, and suggest that HDAC inhibitors may be of potential therapeutic value in the treatment of OA.

TL;DR: Chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondroCytes in alginate is shown.

TL;DR: The systemic administration of TSA ameliorated synovial inflammation in CAIA mice and suppressed cartilage destruction, at least in part, by modulating chondrocyte gene expression.

TL;DR: In this paper, a review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-kappaB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogenactivated protein kinase and c-Jun N-terminal kinase activation.

TL;DR: IL-1beta has a diverse effect on gene expression profile in human chondrocytes affecting matrix genes as well as chemokines and cytokines, and a high likelihood that the most up-regulated chemokine are regulated by the transcription factors myocyte enhancer binding factor-3 (MEF-3), CCAAT/enhancer binding protein (C/EBP) and nuclear factor-kappa B (NF-KappaB).