J
Jakob Hartmann
Researcher at Harvard University
Publications - 48
Citations - 2531
Jakob Hartmann is an academic researcher from Harvard University. The author has contributed to research in topics: Chronic stress & Social defeat. The author has an hindex of 24, co-authored 45 publications receiving 1922 citations. Previous affiliations of Jakob Hartmann include Max Planck Society & McLean Hospital.
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Journal ArticleDOI
FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior
Chadi Touma,Nils C. Gassen,Leonie Herrmann,Joyce Cheung-Flynn,D. Büll,Irina A. Ionescu,J. M. Heinzmann,Alana Knapman,Anna Siebertz,Anna-Mareike Depping,Jakob Hartmann,Felix Hausch,Mathias V. Schmidt,Florian Holsboer,Marcus Ising,Marc B. Cox,Ulrike Schmidt,Theo Rein +17 more
TL;DR: This study in mice and humans presents FKBP5 as a decisive factor for the physiological stress response, shaping neuroendocrine reactivity as well as coping behavior, lending strong support to the concept emerging from human studies of FK BP5 as important factor governing gene-environment interactions relevant for the etiology of affective disorders.
Journal ArticleDOI
The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.
Jakob Hartmann,Klaus V. Wagner,C. Liebl,Sebastian H. Scharf,Xiao-Dong Wang,Miriam Wolf,Felix Hausch,Theo Rein,Ulrike Schmidt,Chadi Touma,Joyce Cheung-Flynn,Marc B. Cox,David F. Smith,Florian Holsboer,Marianne B. Müller,Mathias V. Schmidt +15 more
TL;DR: Results suggest an enhanced negative glucocorticoid feedback within the HPA axis of 51KO mice, possibly modulated by an increased sensitivity of the GR.
Journal ArticleDOI
Selective inhibitors of the FK506-binding protein 51 by induced fit
S. Gaali,Alexander Kirschner,Serena Cuboni,Jakob Hartmann,Christian Kozany,Georgia Balsevich,Christian Namendorf,Paula Fernandez-Vizarra,Claudia Sippel,Anthony S. Zannas,Anthony S. Zannas,Rika Draenert,Elisabeth B. Binder,Elisabeth B. Binder,Osborne F. X. Almeida,Gerd Ruhter,Manfred Uhr,Mathias V. Schmidt,Chadi Touma,Andreas Bracher,Felix Hausch +20 more
TL;DR: It is demonstrated that selective inhibition of FKBP51 enhances neurite elongation in neuronal cultures and improves neuroendocrine feedback and stress-coping behavior in mice, providing the structural and functional basis for the development of mechanistically new antidepressants.
Journal ArticleDOI
Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans
Nils C. Gassen,Jakob Hartmann,Jürgen Zschocke,Jens Stepan,Kathrin Hafner,Andreas Zellner,Thomas Kirmeier,Lorenz K. Kollmannsberger,Klaus V. Wagner,Nina Dedic,Georgia Balsevich,Jan M. Deussing,Stefan Kloiber,Susanne Lucae,Florian Holsboer,Matthias Eder,Manfred Uhr,Marcus Ising,Mathias V. Schmidt,Theo Rein +19 more
TL;DR: Theo Rein and colleagues examine the role of FKBP51 in the actions of antidepressants, with a particular focus on pathways of autophagy.
Journal ArticleDOI
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Nina Dedic,Max L. Pöhlmann,Julia Richter,Divya Mehta,D Czamara,Michael W. Metzger,Julien Dine,Benedikt T. Bedenk,Jakob Hartmann,Jakob Hartmann,Klaus V. Wagner,Angela Jurik,Lynn M. Almli,Adriana Lori,Sven Moosmang,Franz Hofmann,Carsten T. Wotjak,Gerhard Rammes,Matthias Eder,Alon Chen,Alon Chen,Kerry J. Ressler,Kerry J. Ressler,Wolfgang Wurst,Mathias V. Schmidt,Elisabeth B. Binder,Jan M. Deussing +26 more
TL;DR: It is shown that embryonic deletion of Cacna1c in forebrain glutamatergic neurons promotes the manifestation of endophenotypes related to psychiatric disorders including cognitive decline, impaired synaptic plasticity, reduced sociability, hyperactivity and increased anxiety.