U
Umar Mahmood
Researcher at Harvard University
Publications - 221
Citations - 19114
Umar Mahmood is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & In vivo. The author has an hindex of 54, co-authored 207 publications receiving 17286 citations. Previous affiliations of Umar Mahmood include Fox Chase Cancer Center & Cornell University.
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Journal ArticleDOI
Near infrared optical applications in molecular imaging
TL;DR: This review details some of the advances in these areas that have allowed imaging of proteases, apoptosis, and cell surface receptors and details applications in diseases such as cancer, cardiovascular disease, and rheumatoid arthritis.
Journal ArticleDOI
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption
Therese B. Deramaudt,Munenori Takaoka,Rabi Upadhyay,Mark Bowser,Jess Porter,Amy S. Lee,Ben Rhoades,Cameron N. Johnstone,Ralph Weissleder,Sunil R. Hingorani,Umar Mahmood,Anil K. Rustgi +11 more
TL;DR: Molecules that in part are directly affected by Ki-RAS and p53 during pancreatic ductal carcinogenesis are defined and provides a platform for potential new molecularly based therapeutic interventions.
Journal ArticleDOI
13C and 31P NMR investigation of effect of 6-aminonicotinamide on metabolism of RIF-1 tumor cells in vitro.
James C. Street,Umar Mahmood,Douglas Ballon,Alan A. Alfieri,Alan A. Alfieri,Jason A. Koutcher +5 more
TL;DR: Exposure of RIF-1 cells to 6-aminonicotinamide prior to 3- or 6-Gy x-irradiation induced a supra-additive cell kill, indicating that 6-amino-NAD(P), a competitive inhibitor of NAD(P)-requiring processes, is acting as a radiosensitizer.
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Fluorochrome-Functionalized Nanoparticles for Imaging DNA in Biological Systems
Hoonsung Cho,David Alcantara,Hushan Yuan,Rahul A. Sheth,Howard H. Chen,Peng Huang,Sean B. Andersson,David E. Sosnovik,Umar Mahmood,Lee Josephson +9 more
TL;DR: Multiple DNA binding fluorochromes to magnetic nanoparticles provides a way of generating DNA binding NPs that can be used to detect DNA detection by microaggregate formation in vitro, for imaging the DNA of necrotic cells in culture, and for imagingThe DNA of a tumor treated with a chemotherapeutic agent.
Journal ArticleDOI
Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation
Eric S. Martin,Peter J. Belmont,Mark J. Sinnamon,Larissa Georgeon Richard,Jing Yuan,Erin M. Coffee,Jatin Roper,Lydia Lee,Pedram Heidari,Sophia Y. Lunt,Gautam Goel,Xiadong Ji,Zhi Xie,Tao Xie,John Lamb,Scott L. Weinrich,Todd VanArsdale,Roderick T. Bronson,Ramnik J. Xavier,Matthew G. Vander Heiden,Julie L.C. Kan,Umar Mahmood,Kenneth E. Hung +22 more
TL;DR: This approach combines in vitro screening capability using low-passage cell lines that recapitulate human CRC and potential for rapid in vivo validation using cell line-derived tumors that develop in the colonic microenvironment of immunocompetent animals.