U
Umber Alam
Researcher at Islamia University
Publications - 7
Citations - 257
Umber Alam is an academic researcher from Islamia University. The author has contributed to research in topics: Docking (molecular) & Proton NMR. The author has an hindex of 6, co-authored 7 publications receiving 213 citations.
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Journal ArticleDOI
Isolation of natural compounds from Phlomis stewartii showing α-glucosidase inhibitory activity.
Bushra Jabeen,Naheed Riaz,Muhammad Saleem,Muhammad Akram Naveed,Muhammad Ashraf,Umber Alam,Hafiza Mehwish Rafiq,Rasool Bakhsh Tareen,Abdul Jabbar +8 more
TL;DR: The structures of these isolates (1-12) were elucidated by the combination of 1D ((1)H and (13)C NMR), 2D (HMQC, HMBC COSY, NOESY) NMR spectroscopy and mass spectrometry and in comparison with literature data of related compounds.
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Discovery of novel oxindole derivatives as potent α-glucosidase inhibitors.
Momin Khan,Muhammad Yousaf,Abdul Wadood,Muhammad Junaid,Muhammad Ashraf,Umber Alam,Muhammad Ali,Muhammad Arshad,Zahid Hussain,Khalid Mohammed Khan +9 more
TL;DR: A series of 6-chloro-3-oxindole derivatives were synthesized in high yields by the reaction of 6chlorooxindoles with different aromatic aldehydes in the presence of piperidine.
Journal ArticleDOI
Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors.
Madiha Sahar Khan,Munawar Ali Munawar,Mohammad Ashraf,Umber Alam,Athar Ata,Abdullah M. Asiri,Samina Kousar,Misbahul Ain Khan +7 more
TL;DR: A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes.
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Novel synthesis of dihydropyrimidines for α-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking
Muhammad Yar,Marek Bajda,Lubna Shahzadi,Sohail Anjum Shahzad,Maqsood Ahmed,Muhammad Ashraf,Umber Alam,Islam Ullah Khan,Ather Farooq Khan +8 more
TL;DR: The biological assay revealed that the majority of compounds synthesized displayed modest inhibitory activity against α-glucosidase at low micro-molar concentrations, and this method is applicable for various substituted aldehydes as well as urea and thiourea.
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α-Glucosidase inhibitory constituents from Chrozophora plicata
Asia Tabussum,Naheed Riaz,Muhammad Saleem,Muhammad Ashraf,Maqsood Ahmad,Umber Alam,Bushra Jabeen,Abdul Malik,Abdul Jabbar +8 more
TL;DR: In this article, five new secondary metabolites have been isolated from Chrozophora plicata including an acacetin derivative (1), three pyrrole alkaloids plicatanins A-C ( 2 − 4, resp.) and the bilactone plicacanone ( 5 ).