U
Urszula Popowska
Researcher at Gdańsk Medical University
Publications - 7
Citations - 154
Urszula Popowska is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Heat shock protein & Hsp90. The author has an hindex of 4, co-authored 7 publications receiving 128 citations.
Papers
More filters
Journal ArticleDOI
Geldanamycin and its derivatives as Hsp90 inhibitors.
Magdalena M. Gorska,Urszula Popowska,Alicja Sielicka-Dudzin,Alicja Kuban-Jankowska,Wojciech Sawczuk,Narcyz Knap,Giuseppe Cicero,Fabio Wozniak +7 more
TL;DR: The therapeutic usage of geldanamycin has been limited due to its poor water solubility and severe hepatotoxicity, therefore, its analogues, including 17AAG, 17DMAG, Tanespimycin and RetaspimYcin hydrochloride, with improved pharmacokinetic profiles, have been developed.
Journal ArticleDOI
Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)
Magdalena M. Gorska,Antonella Marino Gammazza,Michal A. Zmijewski,Claudia Campanella,Francesco Cappello,Tomasz Wasiewicz,Alicja Kuban-Jankowska,Agnieszka Daca,Alicja Sielicka,Urszula Popowska,Narcyz Knap,Jakub Antoniewicz,Takashi Wakabayashi,Takashi Wakabayashi,Michal Wozniak +14 more
TL;DR: Novel anticancer mechanisms of geldanamycin biological activity are presented and a hypothesis that Hsp60 can be another functional part of mitochondria-related acetylome being a potential target for developing novel anticancer strategies is supported.
Journal ArticleDOI
Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation
Malgorzata Halon,Jan J. Kaczor,Wieslaw Ziolkowski,Damian Jozef Flis,Andzelika Borkowska,Urszula Popowska,Walenty M. Nyka,Michal Wozniak,Jedrzej Antosiewicz +8 more
TL;DR: Multiple mechanisms may underlie iron accumulation in muscles of ALS transgenic rats, which include changes in blood hepcidin and muscle Fpn1 and increased level of muscle ferritin H, suggesting that impaired iron metabolism is not a result of changes in motor activity.
Journal ArticleDOI
JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase
Andzelika Borkowska,Urszula Popowska,Jan Henryk Spodnik,Anna Herman-Antosiewicz,Michał Woźniak,Jedrzej Antosiewicz +5 more
TL;DR: Observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway.
Journal ArticleDOI
Protein tyrosine phosphatase CD45 as a molecular biosensor of hydrogen peroxide generation in cell culture media
TL;DR: The obtained results indicate that production of hydrogen peroxide in the medium leading to inhibition of CD45 was light-dependent, and that careful protection of cell culture media from the light may help to prevent the artifact in cell studies.