V
V. Arena
Researcher at Sapienza University of Rome
Publications - 18
Citations - 465
V. Arena is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Tumor necrosis factor alpha & Colitis. The author has an hindex of 9, co-authored 18 publications receiving 350 citations. Previous affiliations of V. Arena include Boston Children's Hospital.
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Journal ArticleDOI
Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.
Emanuela Sala,Marco Genua,Luciana Petti,Achille Anselmo,V. Arena,Javier Cibella,Lucia Zanotti,Silvia D'Alessio,Franco Scaldaferri,Giovanni Luca,Iva Arato,Riccardo Calafiore,Alessandro Sgambato,Sergio Rutella,Massimo Locati,Silvio Danese,Stefania Vetrano +16 more
TL;DR: BM-MSCs injected into mice with colitis do not localize to the intestine but instead form aggregates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce intestinal inflammation.
Journal ArticleDOI
Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer
Carlotta Tacconi,Federica Ungaro,Carmen Correale,V. Arena,Luca Massimino,Michael Detmar,Antonino Spinelli,Michele Carvello,Massimiliano Mazzone,Ana Isabel Oliveira,Federica Rubbino,Valentina Garlatti,Salvatore Spanò,Enrico Lugli,Federico Colombo,Alberto Malesci,Laurent Peyrin-Biroulet,Stefania Vetrano,Silvio Danese,Silvia D'Alessio +19 more
TL;DR: It is discovered that the VEGFC/VEGFR3 axis can shape both lymphatic endothelial cells (LECs) and TAMs to synergistically inhibit anti-tumor immunity and promote primary CRC growth.
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Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature.
Lorenzo Leggio,Giovanni Addolorato,Ludovico Abenavoli,Anna Ferrulli,Christina D’Angelo,Antonio Mirijello,L. Vonghia,Giovanni Schinzari,V. Arena,Luca Perrone,Franco Citterio,Lorenzo Bonomo,Gian Ludovico Rapaccini,Arnaldo Capelli,Carlo Barone,Giovanni Gasbarrini +15 more
TL;DR: A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported, representing further evidence of a rare malignancy.
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Immunopathological characterization of cryptoglandular anal fistula: a pilot study investigating its pathogenesis
Carlo Ratto,Francesco Litta,Donatella Lucchetti,Angelo Parello,Alma Boninsegna,V. Arena,Lorenza Donisi,Federica Calapà,Alessandro Sgambato +8 more
TL;DR: The pathogenesis of cryptoglandular anal fistula (AF) is still under debate, but tissue inflammation could play a primary role and the pathological process of epithelial mesenchymal transition (EMT) might be involved.
Journal ArticleDOI
The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation
Marco Genua,Silvia D'Alessio,Javier Cibella,Alessandro Gandelli,Emanuela Sala,Carmen Correale,Antonino Spinelli,V. Arena,Alberto Malesci,Sergio Rutella,Victoria A. Ploplis,Stefania Vetrano,Silvio Danese +12 more
TL;DR: Findings point to uPAR as an essential component of intestinal macrophage functions and unravel a new potential target to control mucosal inflammation in IBD.