L
Lorenzo Leggio
Researcher at National Institutes of Health
Publications - 295
Citations - 9745
Lorenzo Leggio is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Alcohol use disorder & Alcohol dependence. The author has an hindex of 47, co-authored 261 publications receiving 7627 citations. Previous affiliations of Lorenzo Leggio include Catholic University of the Sacred Heart & Government of the United States of America.
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Journal ArticleDOI
Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
Giovanni Addolorato,Lorenzo Leggio,Anna Ferrulli,Silvia Cardone,L. Vonghia,Antonio Mirijello,Ludovico Abenavoli,Cristina D'Angelo,Fabio Caputo,Antonella Zambon,Paul S. Haber,Giovanni Gasbarrini +11 more
TL;DR: Baclofen is effective at promoting alcohol abstinence in alcohol-dependent patients with liver cirrhosis and the drug is well tolerated and could have an important role in treatment of these individuals.
Journal ArticleDOI
Acute alcohol intoxication
L. Vonghia,Lorenzo Leggio,Anna Ferrulli,Marco Bertini,Giovanni Gasbarrini,Giovanni Addolorato +5 more
TL;DR: In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established.
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Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study
Alberto Terraneo,Lorenzo Leggio,Lorenzo Leggio,Lorenzo Leggio,Marina Saladini,Mario Ermani,Antonello Bonci,Antonello Bonci,Luigi Gallimberti +8 more
TL;DR: The present preliminary findings support the safety of rTMS in cocaine-addicted patients, and suggest its potential therapeutic role for rT MS-driven PFC stimulation in reducing cocaine use, providing a strong rationale for developing larger placebo-controlled studies.
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Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay
Mary R. Lee,Karl B. Scheidweiler,Xingxing Diao,Fatemeh Akhlaghi,Alex Cummins,Marilyn A. Huestis,Lorenzo Leggio,Lorenzo Leggio,Bruno B. Averbeck +8 more
TL;DR: CSF penetrance of d5, exogenous OT delivered by IN and IV administration is demonstrated and suggests that peripheral administration of OT does not lead to central release of endogenous OT, and that IN administration offered an advantage compared to IV administration with respect to achieving greater CSF concentrations of OT.
Journal ArticleDOI
Advances in the science and treatment of alcohol use disorder
TL;DR: Although recent research has expanded understanding of alcohol use disorder, more research is needed to identify the neurobiological, genetic and epigenetic, psychological, social, and environmental factors most critical in the etiology and treatment of this disease.