V. Srinivasan

TL;DR: Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients.

TL;DR: Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state and by regulating intracellular glutathione levels.

TL;DR: Melatonin’s efficacy in combating free radical damage in the brain suggests that it may be a valuable therapeutic agent in the treatment of cerebral edema after traumatic brain injury.

TL;DR: Various experimental models of AD, PD and HD indicate the usefulness of melatonin in antagonizing disease progression and/or mitigating some of the symptoms, and suggest that melatonin, its analogues and kynuric metabolites may have potential value in prevention and treatment of AD and other neurodegenerative disorders.

TL;DR: Results indicate that exogenous melatonin is more effective to promote sleep in the presence of a diminished production of endogenous melatonin.