V. Suppiah

TL;DR: It is shown that the rs12979860 CC genotype correlates with increased hepatic metallothionein expression through increased systemic zinc levels, providing the first evidence that zinc can act as a potent and specific inhibitor of IFN-λ3 signalling and highlight its potential as a target of therapeutic intervention for IFN -λ3-mediated chronic disease.

TL;DR: For the first time, an association between a cluster of ISGs, the metallothioneins (MTs) and IFNL3 genotype is identified, and MTs were significantly upregulated (in contrast to most other ISGs) in HCV-infected liver biopsies of rs8099917 responders.

TL;DR: This study demonstrated the detection of HCV-specific IFN-γ responses in HCV antibody and RNA negative individuals, with a tendency for HCV -specific IF Nγ responses to be associated with HCV exposure.

TL;DR: Although CCR5-Δ32 may affect viral clearance within closely controlled geographical and genetic environments, it is found no effect in larger cohorts treated with dual therapy, as well as in Australians of European ancestry.