Václav Brázda

TL;DR: Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail and suggest the importance of quadruplex structures in cell processes and their understanding may provide better insight into aging and disease development.

TL;DR: The protein families that are involved in interacting with and regulating cruciform structures, including the junction-resolving enzymes, DNA repair proteins and transcription factors, (c) proteins involved in replication and (d) chromatin-associated proteins are reviewed.

TL;DR: A web version of the G4Hunter application is developed that allows retrieval of gene/nucleotide sequence entries from NCBI databases and provides complete characterization of localization and quadruplex propensity of quadruplex-forming sequences.

TL;DR: Evidence is provided that chronic constriction injury of the rat sciatic nerve induces synthesis of interleukin-6 in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling, which may suggest that unilateral CCI of the sciatics nerve induces bilateral activation of SGC in L4-L5 DRG to transduce IL- 6 signalling during neuroinflammation.

TL;DR: Both HIN domains of IFI16 are capable of enhancing p53-DNA complex formation and transcriptional activation via distinctive means, and both interactions are compatible with the DNA-bound state of p53 and together contribute to the effect of full-length I FI16 on p53.