Zbynek Kozmik

TL;DR: The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.

TL;DR: Complete correlation between the expression pattern of the CD19 gene and the B-cell-specific transcription factor BSAP is demonstrated in a large panel of B-lymphoid cell lines and strongly implicates BSAP in the regulation of theCD19 gene.

TL;DR: Genomic, epigenomic and transcriptomic data derived from the Mediterranean amphioxus provide insights into the evolution of the genomic regulatory landscape of chordates, and pave the way for a better understanding of the regulatory principles that underlie key vertebrate innovations.

TL;DR: It is reported that a gradual retreat of canonical Wnt signaling in the cortex from lateral-to-medial and anterior- to-posterior is a prerequisite of neurogenesis, and it is shown that a sustained canonical WNT activity in the lateral cortex gives rise to cells with hippocampal characteristics in the cortical plate at the expense of the cortical fate.

TL;DR: Deregulation of PAX-5 gene transcription by the t(9;14)(pl3;q32) translocation contributes to the pathogenesis of small lymphocytic lymphomas with plasmacytoid differentiation.