V
Valeh Hadavi
Publications - 21
Citations - 1497
Valeh Hadavi is an academic researcher. The author has contributed to research in topics: Thalassemia & Disease gene identification. The author has an hindex of 12, co-authored 21 publications receiving 1376 citations.
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Journal ArticleDOI
Deep sequencing reveals 50 novel genes for recessive cognitive disorders
Hossein Najmabadi,Hao Hu,Masoud Garshasbi,Tomasz Zemojtel,Seyedeh Sedigheh Abedini,Wei Chen,Masoumeh Hosseini,Farkhondeh Behjati,Stefan A. Haas,Payman Jamali,Agnes Zecha,Marzieh Mohseni,Lucia Püttmann,Leyla Nouri Vahid,C Jensen,Lia Abbasi Moheb,M Bienek,Farzaneh Larti,Ines Mueller,Robert Weissmann,Hossein Darvish,Klaus Wrogemann,Klaus Wrogemann,Valeh Hadavi,Bettina Lipkowitz,Sahar Esmaeeli-Nieh,Dagmar Wieczorek,Roxana Kariminejad,Saghar Ghasemi Firouzabadi,Monika Cohen,Zohreh Fattahi,Imma Rost,Faezeh Mojahedi,Christoph Hertzberg,Atefeh Dehghan,Anna Rajab,Mohammad Javad Soltani Banavandi,Julia Hoffer,Masoumeh Falah,Luciana Musante,Vera M. Kalscheuer,Reinhard Ullmann,Andreas W. Kuss,Andreas Tzschach,Kimia Kahrizi,Hans-Hilger Ropers +45 more
TL;DR: This study, the largest published so far, has revealed additional mutations in 23 genes previously implicated in intellectual disability or related neurological disorders, as well as single, probably disease-causing variants in 50 novel candidate genes.
Journal ArticleDOI
A defect in the TUSC3 gene is associated with autosomal recessive mental retardation.
Masoud Garshasbi,Valeh Hadavi,Haleh Habibi,Kimia Kahrizi,Roxana Kariminejad,Farkhondeh Behjati,Andreas Tzschach,Hossein Najmabadi,Hans-Hilger Ropers,Andreas W. Kuss +9 more
TL;DR: In this article, the authors investigated a large consanguineous family comprising seven patients with nonsyndromic ARMR in four sibships and identified a homozygous deletion of TUSC3 (N33) in all patients.
Journal ArticleDOI
Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci.
Hossein Najmabadi,M. Mahdi Motazacker,Masoud Garshasbi,Kimia Kahrizi,Andreas Tzschach,Wei Chen,Farkhondeh Behjati,Valeh Hadavi,Sahar Esmaeeli Nieh,Seyedeh Sedigheh Abedini,Reza Vazifehmand,Saghar Ghasemi Firouzabadi,Payman Jamali,Masoumeh Falah,Seyed Morteza Seifati,Annette Grüters,Steffen Lenzner,Lars Riff Jensen,Franz Rüschendorf,Andreas W. Kuss,Hans-Hilger Ropers +20 more
TL;DR: Homozygosity mapping in 78 consanguineous Iranian families with nonsyndromic autosomal recessive mental retardation has enabled us to determine the chromosomal localization of at least 8 novel gene loci for this condition.
Journal ArticleDOI
Fourteen-Year Experience of Prenatal Diagnosis of Thalassemia in Iran
Hossein Najmabadi,Alireza Ghamari,Farhad Sahebjam,Roxana Kariminejad,Valeh Hadavi,Talayeh Khatibi,Ashraf Samavat,Elaheh Mehdipour,B Modell,Mohammand Hassan Kariminejad +9 more
TL;DR: The data support the functionality of the Iranian β-thalassemia prevention program and suggest that it might be applied as an adaptive system for neighboring and other Islamic countries.
Journal ArticleDOI
Elucidating the spectrum of α-thalassemia mutations in Iran
Valeh Hadavi,Amir Hossein Taromchi,Mahdi Malekpour,Behjat Gholami,Hai-Yang Law,Navid Almadani,Fariba Afroozan,Farhad Sahebjam,Parisa Pajouh,Roxana Kariminejad,Mohammad Hassan Kariminejad,Azita Azarkeivan,Maryam Jafroodi,Ahmad Tamaddoni,Helene Puehringer,Christian Oberkanins,Hossein Najmabadi +16 more
TL;DR: Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of α-globin mutations in various regions of the country need to be clarified to contribute to a wider understanding of this disorder.