Seyedeh Sedigheh Abedini

TL;DR: This study, the largest published so far, has revealed additional mutations in 23 genes previously implicated in intellectual disability or related neurological disorders, as well as single, probably disease-causing variants in 50 novel candidate genes.

TL;DR: The observations from the Drosophila model point toward an evolutionarily conserved role of RNA methylation in normal cognitive development, suggesting that mutations in this gene might even induce a syndromic form of ID.

TL;DR: This finding provides the first proof that GLU(K6) is indispensable for higher brain functions in humans, and future studies of this and other ionotropic kainate receptors will shed more light on the pathophysiology of mental retardation.

TL;DR: This study, the largest of its kind published to date, illustrates that high-throughput DNA sequencing in consanguineous families is a superior strategy for elucidating the thousands of hitherto unknown gene defects underlying AR-ID, and it sheds light on their prevalence.

TL;DR: Homozygosity mapping in 78 consanguineous Iranian families with nonsyndromic autosomal recessive mental retardation has enabled us to determine the chromosomal localization of at least 8 novel gene loci for this condition.