Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
Chen Liu,David R. Weaver,Xiaowei Jin,Lauren P. Shearman,Rick L. Pieschl,Valentin K. Gribkoff,Steven M. Reppert +6 more
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TLDR
The results provide a molecular basis for two distinct, mechanistically separable effects of melatonin on SCN physiology.About:
This article is published in Neuron.The article was published on 1997-07-01 and is currently open access. It has received 679 citations till now. The article focuses on the topics: Melatonin receptor & Melatonin binding.read more
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Molecular Analysis of Mammalian Circadian Rhythms
TL;DR: Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
Journal ArticleDOI
The neurobiology of sleep: genetics, cellular physiology and subcortical networks.
TL;DR: To appreciate the neural underpinnings of sleep, it is important to view this universal mammalian behaviour at multiple levels of its biological organization.
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Melatonin: Nature's most versatile biological signal?
Seithikurippu R. Pandi-Perumal,V. Srinivasan,Georges J.M. Maestroni,Daniel P. Cardinali,Burkhard Poeggeler,Rüdiger Hardeland +5 more
TL;DR: Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients.
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Functional MT1 and MT2 melatonin receptors in mammals.
TL;DR: The melatonin-mediated responses elicited by activation of MT1 and MT2 native melatonin receptors are dependent on circadian time, duration and mode of exposure to endogenous or exogenous melatonin, and functional receptor sensitivity.
Journal ArticleDOI
Melatonin—A pleiotropic, orchestrating regulator molecule
Rüdiger Hardeland,Daniel P. Cardinali,Venkatramanujam Srinivasan,D. Warren Spence,Gregory M. Brown,Seithikurippu R. Pandi-Perumal +5 more
TL;DR: Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
Simplified mammalian DNA isolation procedure.
TL;DR: This work has simplified the standard mammalian DNA isolation procedure with the aim of minimizing the number of manipulations required for each sample.
Journal ArticleDOI
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
TL;DR: The cloning and characterization of a high affinity receptor for melatonin from the sheep and human is reported, likely mediates the reproductive and circadian actions of melatonin in mammals.
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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
Steven M. Reppert,Catherine Godson,Cathy D. Mahle,David R. Weaver,Susan A. Slaugenhaupt,James F. Gusella +5 more
TL;DR: The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects ofmelatonin in mammals.
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Melatonin shifts human circadian rhythms according to a phase-response curve.
TL;DR: The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel.