Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis

Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

Tribbles: a family of kinase-like proteins with potent signalling regulatory function.

Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several 'independent' signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.

Tribbles: novel regulators of cell function; evolutionary aspects.

https://www.jbc.org/content/271/45/28451.full.pdf

Valérie Savonet

Papers

Identification and Characterization of Novel Genes Modulated in the Thyroid of Dogs Treated with Methimazole and Propylthiouracil

The cAMP in thyroid: from the TSH receptor to mitogenesis and tumorigenesis

11 The cAMP in thyroid