F
Frédérique Coppée
Researcher at Laboratory of Molecular Biology
Publications - 39
Citations - 4207
Frédérique Coppée is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Facioscapulohumeral muscular dystrophy & DUX4. The author has an hindex of 21, co-authored 37 publications receiving 3421 citations. Previous affiliations of Frédérique Coppée include Université libre de Bruxelles & University of Mons.
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Journal ArticleDOI
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Daniele R De Siati,Mihaela Horoi,Serge D Le Bon,Alexandra Rodriguez,Didier Dequanter,Serge Blecic,Fahd El Afia,Lea Distinguin,Younes Chekkoury-Idrissi,Stéphane Hans,Irene Lopez Delgado,Christian Calvo-Henriquez,Philippe Lavigne,Chiara Falanga,Maria Rosaria Barillari,Giovanni Cammaroto,Mohamad Khalife,Pierre Leich,Christel Souchay,Camelia Rossi,Fabrice Journe,Julien Hsieh,Myriam Edjlali,Myriam Edjlali,Robert Carlier,Laurence Ris,Andrea Lovato,Cosimo de Filippis,Frédérique Coppée,Nicolas Fakhry,Tareck Ayad,Sven Saussez +33 more
TL;DR: Olfactory and gustatory disorders are prevalent symptoms in European CO VID-19 patients, who may not have nasal symptoms, and the sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
Journal ArticleDOI
DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1
Manjusha Dixit,Eugénie Ansseau,Alexandra Tassin,Sara T. Winokur,Rongye Shi,Hong Qian,Sébastien Sauvage,Christel Matteotti,Anne Marie Van Acker,Oberdan Leo,Denise A. Figlewicz,Marietta Barro,Dalila Laoudj-Chenivesse,Alexandra Belayew,Frédérique Coppée,Yi-Wen Chen +15 more
TL;DR: The results suggest that up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease.
Journal ArticleDOI
The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.
Valeria Kowaljow,Aline Marcowycz,Eugénie Ansseau,Cecilia Conde,Sébastien Sauvage,Christel Matteotti,Cristina Arias,E. Daniel Corona,Nicolás Gonzalo Núñez,Oberdan Leo,Ruddy Wattiez,Denise A. Figlewicz,Dalila Laoudj-Chenivesse,Alexandra Belayew,Frédérique Coppée,Alberto L. Rosa +15 more
TL;DR: It is proposed that DUX4-mediated cell death contributes to the pathogenic pathway in FSHD and is endogenously expressed in nuclei of adult and fetal human rhabdomyosarcoma cell lines.
Journal ArticleDOI
An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies.
Darko Bosnakovski,Zhaohui Xu,Eun Ji Gang,Cristi L. Galindo,Mingju Liu,Tugba Simsek,Harold R. Garner,Siamak Agha-Mohammadi,Alexandra Tassin,Frédérique Coppée,Alexandra Belayew,Rita R.C. Perlingeiro,Michael Kyba +12 more
TL;DR: A novel genetic tool, inducible cassette exchange, enabling rapid generation of isogenetically modified cells with conditional and variable transgene expression is described, and a hypothesis for FSHD is proposed in which DUX4 expression interferes with Pax7 in satellite cells, and inappropriately regulates Pax targets, including myogenic regulatory factors, during regeneration.
Journal ArticleDOI
DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo.
Lindsay M. Wallace,Sara E. Garwick,Wenyan Mei,Wenyan Mei,Alexandra Belayew,Frédérique Coppée,Katherine J. Ladner,Denis C. Guttridge,Jing Yang,Jing Yang,Scott Q. Harper,Scott Q. Harper +11 more
TL;DR: The objective was to test the in vivo myopathic potential of DUX4, and recent evidence supports a role for the D4Z4‐encoded Dux4 gene in FSHD.