S
Stefania Nicoli
Researcher at Yale University
Publications - 55
Citations - 2644
Stefania Nicoli is an academic researcher from Yale University. The author has contributed to research in topics: Zebrafish & Angiogenesis. The author has an hindex of 23, co-authored 49 publications receiving 2338 citations. Previous affiliations of Stefania Nicoli include University of Brescia & University of Massachusetts Medical School.
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MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
TL;DR: This work describes a novel genetic mechanism in which a microRNA facilitates integration of a physiological stimulus with growth factor signalling in endothelial cells to guide angiogenesis.
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Mammalian Tumor Xenografts Induce Neovascularization in Zebrafish Embryos
TL;DR: The zebrafish/tumor xenograft model represents a novel tool for investigating the neovascularization process exploitable for drug discovery and gene targeting in tumor angiogenesis and VE-cadherin gene inactivation by antisense morpholino oligonucleotide injection inhibits tumor neov vessel development.
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The Zebrafish/Tumor Xenograft Angiogenesis Assay
Stefania Nicoli,Marco Presta +1 more
TL;DR: The method is rapid and inexpensive, representing a novel tool for investigating tumor angiogenesis and for antiangiogenic drug discovery, and gene inactivation by antisense morpholino oligonucleotides injection in zebrafish embryos may allow the identification of genes involved in tumorAngiogenesis.
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miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development
Stefania Nicoli,Carl-Philipp Knyphausen,Carl-Philipp Knyphausen,Lihua Julie Zhu,Abirami Lakshmanan,Nathan D. Lawson +5 more
TL;DR: Deep sequencing and functional screening in zebrafish finds that miR-221 is essential for angiogenesis, and is identified as an important regulatory node through which tip cell migration and proliferation are controlled duringAngiogenesis.
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Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Nicolas Baeyens,Stefania Nicoli,Brian G. Coon,Tyler D Ross,Koen van den Dries,Jinah Han,Holly M. Lauridsen,Cecile O. Mejean,Anne Eichmann,Jean-Leon Thomas,Jay D. Humphrey,Martin A. Schwartz +11 more
TL;DR: Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling, providing direct evidence for a fluid shear stress set point and identifying a mechanism for varying the set point.