K
Konstantinos Evangelou
Researcher at National and Kapodistrian University of Athens
Publications - 60
Citations - 3981
Konstantinos Evangelou is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Senescence & Cancer. The author has an hindex of 25, co-authored 55 publications receiving 2580 citations. Previous affiliations of Konstantinos Evangelou include University College London & University of Ioannina.
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Journal ArticleDOI
Cellular Senescence: Defining a Path Forward
Vassilis G. Gorgoulis,Peter D. Adams,Andrea Alimonti,Dorothy C. Bennett,Oliver Bischof,Cleo L. Bishop,Judith Campisi,Manuel Collado,Konstantinos Evangelou,Gerardo Ferbeyre,Jesús Gil,Eiji Hara,Valery Krizhanovsky,Diana Jurk,Andrea B. Maier,Masashi Narita,Laura J. Niedernhofer,João F. Passos,Paul D. Robbins,Clemens A. Schmitt,John M. Sedivy,Konstantinos Vougas,Thomas von Zglinicki,Daohong Zhou,Manuel Serrano,Marco Demaria +25 more
TL;DR: A consensus from the International Cell Senescence Association (ICSA) is presented, defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers.
Journal ArticleDOI
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.
Eleni A Georgakopoulou,Katerina Tsimaratou,Konstantinos Evangelou,Marcos-PJ Fernandez,Vassilis Zoumpourlis,Ioannis P. Trougakos,Dimitris Kletsas,Jiri Bartek,Manuel Serrano,Vassilis G. Gorgoulis +9 more
TL;DR: This work validated the histochemical Sudan-Black-B (SBB) specific stain of lipofuscin, an aggregate of oxidized proteins, lipids and metals, known to accumulate in aged tissues, as an additional reliable approach to detect senescent cells independently of sample preparation, strongly supporting the candidacy of lip ofuscin for a biomarker of cellular senescence.
Journal ArticleDOI
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Sotirios K. Sotiriou,Irene Kamileri,Natalia Lugli,Konstantinos Evangelou,Caterina Da-Ré,Florian Huber,Laura Padayachy,Sébastien Tardy,Noemie L. Nicati,Samia Barriot,Fena Ochs,Claudia Lukas,Jiri Lukas,Vassilis G. Gorgoulis,Leonardo Scapozza,Thanos D. Halazonetis +15 more
TL;DR: In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan and it is proposed that mammalian RAD52 facilitates repair of collapsed DNA replication forks in cancer cells.
Journal ArticleDOI
Ageing, Cellular Senescence and Neurodegenerative Disease.
Marios Kritsilis,Sophia V. Rizou,Paraskevi N. Koutsoudaki,Konstantinos Evangelou,Vassilis G. Gorgoulis,Dimitrios Papadopoulos +5 more
TL;DR: Evidence of cellular senescence in neurons and glial cells is reviewed and its putative role in Alzheimer's disease, Parkinson’s disease and multiple sclerosis is discussed and a novel GL13 lipofuscin stain is provided, for the first time, using the novelGL13 lip ofuscin Stain as a marker of cellularsenescence.
Journal ArticleDOI
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Michalis Liontos,Marilena Koutsami,Maria Sideridou,Konstantinos Evangelou,Dimitris Kletsas,Brynn Levy,Athanassios Kotsinas,Odelia Nahum,Vassilis Zoumpourlis,Mirsini Kouloukoussa,Zoi Lygerou,Stavros Taraviras,Christos Kittas,Jirina Bartkova,Athanasios G. Papavassiliou,Jiri Bartek,Thanos D. Halazonetis,Vassilis G. Gorgoulis +17 more
TL;DR: Stable expression of hCdc6 and hCdt1 in premalignant papilloma cells led to transformation of the cells that produced tumors upon injection into nude mice depicting the oncogenic potential of their deregulation.