V
Venkitasamy Kesavan
Researcher at Indian Institute of Technology Madras
Publications - 86
Citations - 3945
Venkitasamy Kesavan is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 22, co-authored 83 publications receiving 3728 citations. Previous affiliations of Venkitasamy Kesavan include Centre national de la recherche scientifique & Alnylam Pharmaceuticals.
Papers
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Journal ArticleDOI
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek,Akin Akinc,Birgit Bramlage,Klaus Charisse,Rainer Constien,Mary Donoghue,Sayda Elbashir,Anke Geick,Philipp Hadwiger,Jens Harborth,Matthias John,Venkitasamy Kesavan,Gary Lavine,Rajendra K. Pandey,Timothy Racie,Kallanthottathil G. Rajeev,Ingo Röhl,Ivanka Toudjarska,Gang Wang,Silvio Wuschko,David Bumcrot,Victor Koteliansky,Stefan Limmer,Muthiah Manoharan,Hans-Peter Vornlocher +24 more
TL;DR: In this article, chemically modified short interfering RNAs (siRNAs) were used to silence an endogenous gene encoding apolipoprotein B (apoB) after intravenous injection in mice.
Patent
Chemically modified oligonucleotides
TL;DR: In this paper, the authors described composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression in order to prevent gene expression from being suppressed.
Journal ArticleDOI
Facile ring opening of oxiranes with aromatic amines in fluoro alcohols
Journal ArticleDOI
Catalytic Aerobic Oxidation of Cycloalkanes with Nanostructured Amorphous Metals and Alloys
Venkitasamy Kesavan,Pennadam S. Sivanand,Srinivasan Chandrasekaran,Yuri Koltypin,Aharon Gedanken +4 more
TL;DR: Under mild conditions (40 atm O(2), 28 degrees C, 10-15 h), an efficient aerobic oxidation ofcycloalkanes to cycloalkanols can be achieved using nanostructured amorphous metals such as Fe and Co and anAmorphous alloy like Fe(20)Ni(80) as catalysts.
Journal ArticleDOI
Enantioselective Synthesis of Dihydrospiro[indoline-3,4'-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction.
TL;DR: A new bifunctional squaramide organocatalyst derived from L-proline mediated the first enantioselective synthesis of dihydrospiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in excellent enantiOSElectivity by reacting pyrazolones with isatylidine β,γ-unsaturated α-ketoester.