Journal ArticleDOI
Enantioselective Synthesis of Dihydrospiro[indoline-3,4'-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction.
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TLDR
A new bifunctional squaramide organocatalyst derived from L-proline mediated the first enantioselective synthesis of dihydrospiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in excellent enantiOSElectivity by reacting pyrazolones with isatylidine β,γ-unsaturated α-ketoester.About:
This article is published in Organic Letters.The article was published on 2016-03-04. It has received 91 citations till now. The article focuses on the topics: Pyrazole & Squaramide.read more
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Catalytic asymmetric synthesis of spirooxindoles: recent developments
Guang-Jian Mei,Feng Shi +1 more
TL;DR: This feature article outlines the recent progress in the catalytic asymmetric synthesis of spirooxindoles, including the contributions of the group of scientists from the University of California, Berkeley.
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New development in the enantioselective synthesis of spiro compounds
TL;DR: The aim of this review is to summarize the latest trends and developments in the enantioselective synthesis of spirocompounds during these last six years.
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Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters
TL;DR: The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary carbon stereocenter is currently of great interest because such privileged 3D structures are widely present in natural products that exhibit a broad spectrum of biological and pharmacological activities as discussed by the authors.
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Stereoselective synthesis and applications of spirocyclic oxindoles
Alexander J. Boddy,James A. Bull +1 more
TL;DR: In this paper, the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3-to 8-membered rings is discussed.
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Pyrazolone: a powerful synthon for asymmetric diverse derivatizations
TL;DR: This feature article summarizes these excellent research studies since 2015, including some efforts by the group of researchers studying the catalytic asymmetric synthesis of 4-monosubstituted, 4-disubst ituted, fused and spiro pyrazoles/pyrazolones.
References
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Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
TL;DR: The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
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From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.
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Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies
TL;DR: This review focuses on the enantioselective synthesis of spirooxindoles via organocascade strategies and is organized on the basis of three primary starting materials and then further subdivided according to the types of organocatalyst.
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Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis
TL;DR: In this minireview, squaramides are presented from their roots as artificial anion receptors in molecular recognition studies to their recent advances as powerful bifunctional hydrogen-bonding catalysts in asymmetric organocatalysis.
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Metabolism of fluorine-containing drugs.
TL;DR: The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.