V
Veronica Garcia
Researcher at Celera Corporation
Publications - 11
Citations - 3092
Veronica Garcia is an academic researcher from Celera Corporation. The author has contributed to research in topics: Single-nucleotide polymorphism & Haplotype. The author has an hindex of 9, co-authored 11 publications receiving 2994 citations.
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Journal ArticleDOI
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Ann B. Begovich,Victoria E.H. Carlton,Lee Honigberg,Steven J. Schrodi,Anand P. Chokkalingam,Heather C. Alexander,Kristin G. Ardlie,Qiqing Huang,Ashley M. Smith,Jill M. Spoerke,Marion T. Conn,Monica Chang,Sheng Yung P Chang,Randall K. Saiki,Joseph J. Catanese,Diane U. Leong,Veronica Garcia,Linda B. McAllister,Douglas A. Jeffery,Annette Lee,Franak Batliwalla,Elaine F. Remmers,Lindsey A. Criswell,Michael F. Seldin,Daniel L. Kastner,Christopher I. Amos,John J. Sninsky,Peter K. Gregersen +27 more
TL;DR: It is shown that the risk allele of a missense SNP in PTPN22 disrupts the P1 proline-rich motif that is important for interaction with Csk, potentially altering these proteins' normal function as negative regulators of T-cell activation.
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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
Michele Cargill,Steven J. Schrodi,Monica Chang,Veronica Garcia,Rhonda C. Brandon,Kristina P. Callis,Nori Matsunami,Kristin G. Ardlie,Daniel Civello,Joseph J. Catanese,Diane U. Leong,Jackie M. Panko,Linda B. McAllister,Christopher B. Hansen,Jason Papenfuss,Stephen M. Prescott,Thomas J. White,Mark Leppert,Gerald G. Krueger,Ann B. Begovich +19 more
TL;DR: A multitiered, case-control association study of psoriasis in three independent sample sets of white North American individuals found a highly significant association with an IL12B 3'-untranslated-region SNP (rs3212227), confirming the results of a small Japanese study.
Journal ArticleDOI
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
Yonghong Li,Petra Nowotny,Peter Holmans,Scott Smemo,John S. K. Kauwe,Anthony L. Hinrichs,Kristina Tacey,Lisa Doil,Ryan van Luchene,Veronica Garcia,Charles M. Rowland,Steven J. Schrodi,Diane Leong,Goran Gogic,Joanne Chan,Anibal Cravchik,David A. Ross,Kit Lau,Shirley Kwok,Sheng-Yung Chang,Joseph J. Catanese,John J. Sninsky,Thomas J. White,John Hardy,John Powell,Simon Lovestone,John C. Morris,Leon J. Thal,Michael John Owen,Julie Williams,Alison Goate,Andrew Grupe +31 more
TL;DR: A large-scale single-nucleotide polymorphism (SNP)-based association study across the region of linkage on chromosome 12 in multiple case-control series raises the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis.
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A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
Monica Chang,Charles M. Rowland,Veronica Garcia,Steven J. Schrodi,Joseph J. Catanese,Annette H M van der Helm-van Mil,Kristin G. Ardlie,Christopher I. Amos,Lindsey A. Criswell,Daniel L. Kastner,Peter K. Gregersen,Fina A S Kurreeman,René E. M. Toes,Tom W J Huizinga,Michael F. Seldin,Ann B. Begovich +15 more
TL;DR: In combination with the other two known genetic risk factors, HLA-DRB1 and PTPN22, the variants reported here generate more than a 45-fold RA-risk differential.
Journal ArticleDOI
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
Yonghong Li,Monica Chang,Olivia T. Abar,Veronica Garcia,Charles M. Rowland,Joseph J. Catanese,David Ross,Samuel Broder,Mitchell L. Shiffman,Ramsey Cheung,Teresa L. Wright,Scott L. Friedman,John J. Sninsky +12 more
TL;DR: Multiple variants in TLR4 and STXBP5L genes modulate risk of liver fibrosis and are of relevance for understanding the pathogenesis of HCV-induced liver disease in Caucasians and may be extended to other ethnicities as well.