S
Scott Smemo
Researcher at Washington University in St. Louis
Publications - 18
Citations - 2754
Scott Smemo is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Single-nucleotide polymorphism & Allele. The author has an hindex of 15, co-authored 18 publications receiving 2421 citations. Previous affiliations of Scott Smemo include Columbia University & NewYork–Presbyterian Hospital.
Papers
More filters
Journal ArticleDOI
Obesity-associated variants within FTO form long-range functional connections with IRX3
Scott Smemo,Juan J. Tena,Kyoung-Han Kim,Eric R. Gamazon,Noboru J. Sakabe,Carlos Gómez-Marín,Ivy Aneas,Flavia L. Credidio,Débora R. Sobreira,Nora F. Wasserman,Ju Hee Lee,Vijitha Puviindran,Davis Tam,Michael Shen,Joe Eun Son,Niki Alizadeh Vakili,Hoon Ki Sung,Silvia Naranjo,Rafael D. Acemel,Miguel Manzanares,Andras Nagy,Nancy J. Cox,Chi-chung Hui,José Luis Gómez-Skarmeta,Marcelo A. Nobrega +24 more
TL;DR: It is shown that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3, and long-range enhancers within this region recapitulate aspects of IRx3 expression, suggesting that the Obesity-associated interval belongs to the regulatory landscape ofIRX3.
Journal ArticleDOI
FTO-Mediated Formation of N6-Hydroxymethyladenosine and N6-Formyladenosine in Mammalian RNA
Ye Fu,Guifang Jia,Xueqin Pang,Xueqin Pang,Richard N. Wang,Xiao Wang,Charles J. Li,Scott Smemo,Qing Dai,Kathleen A. Bailey,Marcelo A. Nobrega,Ke-Li Han,Qiang Cui,Chuan He +13 more
TL;DR: It is shown that FeII- and α-ketoglutarate (α-KG)-dependent fat mass and obesity associated (FTO) protein oxidizes m6A to generates hm 6A as an intermediate modification and f6A as a further oxidized product.
Journal ArticleDOI
Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease
Scott Smemo,Luciene Cristina Gastalho Campos,Ivan P. Moskowitz,José Eduardo Krieger,Alexandre C. Pereira,Marcelo A. Nobrega +5 more
TL;DR: It is demonstrated that a single-base-pair mutation abrogates the ability of the enhancer to drive expression within the heart in vivo using both mouse and zebrafish transgenic models, effectively decoupling the heart and hand phenotypes of the Holt-Oram syndrome.
Journal ArticleDOI
A common genetic variant within SCN10A modulates cardiac SCN5A expression
Malou van den Boogaard,Scott Smemo,Ozanna Burnicka-Turek,David E. Arnolds,Harmen J.G. van de Werken,Petra Klous,David M. McKean,Jochen D. Muehlschlegel,Julia Moosmann,Okan Toka,Xinan Yang,Tamara T. Koopmann,Michiel E. Adriaens,Connie R. Bezzina,Wouter de Laat,Christine E. Seidman,Jonathan G. Seidman,Vincent M. Christoffels,Marcelo A. Nobrega,Phil Barnett,Ivan P. Moskowitz +20 more
TL;DR: By high-resolution 4C-seq analysis of the Scn10a-Scn5a locus in murine heart tissue, a genomic mechanism for how a common genetic variation at SCN10A influences cardiac physiology and predisposes to arrhythmia is established.
Journal ArticleDOI
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
Andrew Grupe,Yonghong Li,Charles M. Rowland,Petra Nowotny,Anthony L. Hinrichs,Scott Smemo,John S. K. Kauwe,Taylor J. Maxwell,Sara Cherny,Lisa Doil,Kristina Tacey,Ryan van Luchene,Amanda J. Myers,Fabienne Wavrant-De Vrièze,Mona Kaleem,Paul Hollingworth,Luke Jehu,Catherine Foy,Nicola Archer,Gillian Hamilton,Peter Holmans,Christopher Morris,Joseph J. Catanese,John J. Sninsky,Thomas J. White,John Powell,John Hardy,Michael Conlon O'Donovan,Simon Lovestone,Lesley Jones,John C. Morris,Leon J. Thal,Michael John Owen,Julie Williams,Alison Goate +34 more
TL;DR: Results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.