F
Fina A S Kurreeman
Researcher at Leiden University Medical Center
Publications - 59
Citations - 5949
Fina A S Kurreeman is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 32, co-authored 59 publications receiving 5515 citations. Previous affiliations of Fina A S Kurreeman include Leiden University & Harvard University.
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Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.
Journal ArticleDOI
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Annette Lee,Rachel Hackett,Candace Guiducci,Noël P. Burtt,Lauren Gianniny,Benjamin D. Korman,Leonid Padyukov,Fina A S Kurreeman,Monica Chang,Joseph J. Catanese,Bo Ding,Sandra Wong,Annette H M van der Helm-van Mil,Benjamin M. Neale,Benjamin M. Neale,Benjamin M. Neale,Jonathan S. Coblyn,Jing Cui,Paul P. Tak,Gertjan Wolbink,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Lindsey A. Criswell,Christopher I. Amos,Michael F. Seldin,Daniel L. Kastner,Kristin G. Ardlie,Lars Alfredsson,Karen H. Costenbader,David Altshuler,David Altshuler,Tom W J Huizinga,Nancy A. Shadick,Michael E. Weinblatt,Niek de Vries,Jane Worthington,Mark Seielstad,René E. M. Toes,Elizabeth W. Karlson,Ann B. Begovich,Lars Klareskog,Peter K. Gregersen,Mark J. Daly,Mark J. Daly,Robert M. Plenge,Robert M. Plenge,Robert M. Plenge +50 more
TL;DR: To identify rheumatoid arthritis risk loci in European populations, a meta-analysis of two published genome-wide association studies totaling 3,393 cases and 12,462 controls identified a common variant at the CD40 gene locus and identified evidence of association at four additional gene loci.
Journal ArticleDOI
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Eli A. Stahl,Daniel Wegmann,Gosia Trynka,Javier Gutierrez-Achury,Ron Do,Ron Do,Benjamin F. Voight,Peter Kraft,Robert Chen,Robert Chen,Henrik Källberg,Fina A S Kurreeman,Fina A S Kurreeman,Diabetes Genetics Replication,Diabetes Genetics Replication,Sekar Kathiresan,Sekar Kathiresan,Cisca Wijmenga,Peter K. Gregersen,Lars Alfredsson,Katherine A. Siminovitch,Jane Worthington,Paul I.W. de Bakker,Soumya Raychaudhuri,Soumya Raychaudhuri,Robert M. Plenge,Robert M. Plenge +26 more
TL;DR: The genetic architecture underlying genome-wide association study (GWAS) data for rheumatoid arthritis is modeled and a new method using polygenic risk-score analyses to infer the total liability-scale variance explained by associated GWAS SNPs is developed.
Journal ArticleDOI
Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk
Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Brian Thomson,Elaine F. Remmers,Stephen Eyre,Anne Hinks,Candace Guiducci,Joseph J. Catanese,Gang Xie,Eli A. Stahl,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Noël P. Burtt,Monica Chang,Jonathan S. Coblyn,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Phillip L. De Jager,Phillip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Fina A S Kurreeman,Fina A S Kurreeman,Annette Lee,Xiangdong Liu,Yonghong Li,Paul Martin,Ann W. Morgan,Leonid Padyukov,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,Paul Wordsworth,David Altshuler,David Altshuler,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Katherine A. Siminovitch,Jane Worthington,Lars Klareskog,Peter K. Gregersen,Mark J. Daly,Mark J. Daly,Robert M. Plenge,Robert M. Plenge +69 more
TL;DR: To discover new rheumatoid arthritis risk loci, GRAIL used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining to PubMed abstracts, to score these 179 loci for functional relationships to genes in 16 established RA disease loci.
Journal ArticleDOI
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
Alexandra Zhernakova,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Gosia Trynka,Soumya Raychaudhuri,Eleanora A. Festen,Lude Franke,Harm-Jan Westra,Rudolf S N Fehrmann,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Brian Thomson,Namrata Gupta,Jihane Romanos,Ross McManus,Anthony W. Ryan,Graham Turner,Elisabeth Brouwer,M. D. Posthumus,Elaine F. Remmers,Francesca Tucci,René E. M. Toes,Elvira Grandone,Maria Cristina Mazzilli,Anna Rybak,Bożena Cukrowska,Marieke J H Coenen,Timothy R D J Radstake,Piet L. C. M. van Riel,Yonghong Li,Paul I.W. de Bakker,Peter K. Gregersen,Jane Worthington,Katherine A. Siminovitch,Lars Klareskog,Tom W J Huizinga,Cisca Wijmenga,Robert M. Plenge,Robert M. Plenge +41 more
TL;DR: A meta-analysis of two published GWAS on celiac disease and rheumatoid arthritis confirmed that 4 gene loci previously established in either CD or RA are associated with the other autoimmune disease at combined P<5×10−8, and implicate antigen presentation and T-cell activation as a shared mechanism of disease pathogenesis.