Victor J. Marder

TL;DR: The data suggest that the Weibel- Palade bodies of endothelial cells are storage and/or processing organelles for von Willebrand protein in the perinuclear region, in small rodlike structures through the cytoplasm and on filaments of the extracellular matrix.

TL;DR: One decade after the Food and Drug Administration approved the plasminogen activators streptokinase and urokinase, thrombolytic therapy is no longer a novel approach to the treatment of thrombotic disease.

TL;DR: Intraarterial thrombolytic therapy was associated with a reduction in the incidence of in-hospital cardiopulmonary complications and a corresponding increase in patient survival rates, suggesting that thrombotic therapy may offer a safe and effective alternative to operation in the initial treatment of patients diagnosed with acute limb-threatening peripheral arterial occlusion.

TL;DR: Endothelial cells concentrate a special subclass of very large and biologically potent vWf multimers in Weibel-Palade bodies, presumably available for release in response to vascular injury.

TL;DR: It is indicated that a procoagulant state, as reflected in elevated levels of D-dimer, and disordered lipid transport, as indicated by low apoA-1 and high apoB levels, contribute independently to recurrent coronary events in postinfarction patients.