V
Victoria A. Graham
Researcher at Public Health England
Publications - 32
Citations - 1806
Victoria A. Graham is an academic researcher from Public Health England. The author has contributed to research in topics: Virus & Zika virus. The author has an hindex of 11, co-authored 26 publications receiving 1234 citations.
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Journal ArticleDOI
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Karin Stettler,Martina Beltramello,Diego A. Espinosa,Victoria A. Graham,Antonino Cassotta,Antonino Cassotta,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Stefano Jaconi,Federico Mele,Mathilde Foglierini,Mattia Pedotti,Luca Simonelli,Stuart D. Dowall,Barry Atkinson,Elena Percivalle,Cameron P. Simmons,Cameron P. Simmons,Luca Varani,Johannes Blum,Johannes Blum,Fausto Baldanti,Elisabetta Cameroni,Roger Hewson,Eva Harris,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Davide Corti +29 more
TL;DR: The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.
Journal ArticleDOI
A Susceptible Mouse Model for Zika Virus Infection.
Stuart D. Dowall,Victoria A. Graham,Emma Rayner,Barry Atkinson,Graham Hall,Robert J. Watson,Andrew Bosworth,Laura C. Bonney,Samantha Kitchen,Roger Hewson +9 more
TL;DR: A129 mice are identified as being highly susceptible to ZIKV and thus A129 mice represent a suitable, and urgently required, small animal model for the testing of vaccines and antivirals.
Journal ArticleDOI
Exportation of Monkeypox virus from the African continent.
Matthew R. Mauldin,Andrea M. McCollum,Yoshinori J. Nakazawa,Anna Mandra,Erin R. Whitehouse,Whitni Davidson,Hui Zhao,Jinxin Gao,Yu Li,Jeffrey B. Doty,Adesola Yinka-Ogunleye,Afolabi Akinpelu,Olusola Aruna,Dhamari Naidoo,Kuiama Lewandowski,Babak Afrough,Victoria A. Graham,Emma Aarons,Roger Hewson,Richard Vipond,Jake Dunning,Meera Chand,Colin S Brown,Inbar Cohen-Gihon,Noam Erez,Ohad Shifman,Ofir Israeli,Melamed Sharon,Eli Schwartz,Adi Beth-Din,Anat Zvi,Tze Minn Mak,Yi Kai Ng,Lin Cui,Raymond T. P. Lin,Victoria A. Olson,Tim Brooks,Nir Paran,Chikwe Ihekweazu,Mary G. Reynolds +39 more
TL;DR: Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections.
Journal ArticleDOI
A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
Jiaqi Wang,Marco Bardelli,Diego A. Espinosa,Mattia Pedotti,T.S. Ng,Siro Bianchi,Luca Simonelli,Elisa X.Y. Lim,Mathilde Foglierini,Fabrizia Zatta,Stefano Jaconi,Martina Beltramello,Elisabetta Cameroni,Guntur Fibriansah,Jian Shi,Taylor Barca,Isabel Pagani,Alicia Rubio,Vania Broccoli,Elisa Vicenzi,Victoria A. Graham,Steven T. Pullan,Stuart D. Dowall,Roger Hewson,Simon Jurt,Oliver Zerbe,Karin Stettler,Antonio Lanzavecchia,Federica Sallusto,Andrea Cavalli,Eva Harris,Shee-Mei Lok,Luca Varani,Davide Corti +33 more
TL;DR: A bispecific antibody comprising ZKA190 and a second mAb specific for DII of E protein, FIT-1 robustly prevented viral escape, warranting its development as a ZIKV immunotherapy.
Journal ArticleDOI
Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques.
Graham J. Hatch,Victoria A. Graham,Kevin R. Bewley,Julia A. Tree,Mike Dennis,Irene Taylor,Simon G. P. Funnell,Simon R. Bate,Kimberley Steeds,Thomas Tipton,Thomas Bean,Laura Hudson,Deborah J. Atkinson,Gemma McLuckie,Melanie Charlwood,Allen D. G. Roberts,Julia Vipond +16 more
TL;DR: A monkeypox model of infection in cynomolgus macaques was used to evaluate two vaccines, Acam2000 and Imvamune, for protection against disease and found no significant difference between the levels of neutralizing antibody.