M
Mattia Pedotti
Researcher at University of Lugano
Publications - 38
Citations - 2318
Mattia Pedotti is an academic researcher from University of Lugano. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 14, co-authored 30 publications receiving 1821 citations. Previous affiliations of Mattia Pedotti include University of Insubria.
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Journal ArticleDOI
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Karin Stettler,Martina Beltramello,Diego A. Espinosa,Victoria A. Graham,Antonino Cassotta,Antonino Cassotta,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Stefano Jaconi,Federico Mele,Mathilde Foglierini,Mattia Pedotti,Luca Simonelli,Stuart D. Dowall,Barry Atkinson,Elena Percivalle,Cameron P. Simmons,Cameron P. Simmons,Luca Varani,Johannes Blum,Johannes Blum,Fausto Baldanti,Elisabetta Cameroni,Roger Hewson,Eva Harris,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Davide Corti +29 more
TL;DR: The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.
Journal ArticleDOI
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
Milena Schiraldi,Angela Raucci,Laura Martínez Muñoz,Elsa Livoti,Barbara Celona,Emilie Venereau,Tiziana Apuzzo,Francesco De Marchis,Mattia Pedotti,Angela Bachi,Marcus Thelen,Luca Varani,Mario Mellado,Amanda E. I. Proudfoot,Marco Bianchi,Mariagrazia Uguccioni +15 more
TL;DR: CXCL12 forms a complex with HMGB1 that binds to the chemokine receptor CXCR4 and increases inflammatory cell migration and increasesinflammatory cell migration.
Journal ArticleDOI
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
Davide Corti,Jincun Zhao,Mattia Pedotti,Luca Simonelli,Sudhakar Agnihothram,Craig Fett,Blanca Fernandez-Rodriguez,Mathilde Foglierini,Gloria Agatic,Fabrizia Vanzetta,Robin Gopal,Christopher J. Langrish,Nicholas A Barrett,Federica Sallusto,Ralph S. Baric,Luca Varani,Maria Zambon,Stanley Perlman,Antonio Lanzavecchia,Antonio Lanzavecchia +19 more
TL;DR: The isolation of a potent MERS-CoV–neutralizing antibody from memory B cells of an infected individual is described, for the first time, and this antibody, named LCA60, binds to a novel site on the spike protein and potently neutralizes infection of multiple MSPs isolates by interfering with the binding to the cellular receptor CD26.
Journal ArticleDOI
A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
Jiaqi Wang,Marco Bardelli,Diego A. Espinosa,Mattia Pedotti,T.S. Ng,Siro Bianchi,Luca Simonelli,Elisa X.Y. Lim,Mathilde Foglierini,Fabrizia Zatta,Stefano Jaconi,Martina Beltramello,Elisabetta Cameroni,Guntur Fibriansah,Jian Shi,Taylor Barca,Isabel Pagani,Alicia Rubio,Vania Broccoli,Elisa Vicenzi,Victoria A. Graham,Steven T. Pullan,Stuart D. Dowall,Roger Hewson,Simon Jurt,Oliver Zerbe,Karin Stettler,Antonio Lanzavecchia,Federica Sallusto,Andrea Cavalli,Eva Harris,Shee-Mei Lok,Luca Varani,Davide Corti +33 more
TL;DR: A bispecific antibody comprising ZKA190 and a second mAb specific for DII of E protein, FIT-1 robustly prevented viral escape, warranting its development as a ZIKV immunotherapy.
Journal ArticleDOI
Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors
Rita La Spina,Valentina E. V. Ferrero,Venera Aiello,Mattia Pedotti,Luca Varani,Teresa Lettieri,Luigi Calzolai,Willem Haasnoot,Pascal Colpo +8 more
TL;DR: A label-free surface plasmon resonance (SPR) biosensor method to detect specific EDCs through their binding to estrogen receptor alpha (ERα) and a SPR assay that combines a conformation-sensitive peptide with an array of ERα mutants is very promising for the assessment of the risk of potential estrogenic activity for chemical substances.